#Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut pmrA pmrA 15 GGG G R Colistin 19332669,2550546 Target modification pmrA pmrA 53 GGG G E,R Colistin 19332669,19332669 Target modification pmrB pmrA 81 CGC R C,H Colistin 19332669,19332669 Target modification pmrB pmrB 14 TTA L S,F Colistin 19332669,19332669 Target modification pmrB pmrB 22 CTG L P Colistin 19332669 Target modification pmrB pmrB 29 AGT S R Colistin 19332669 Target modification pmrB pmrB 92 ACC T A Colistin 19332669 Target modification pmrB pmrB 94 CCG P Q Colistin 19332669 Target modification pmrB pmrB 121 GAG E A Colistin 19332669 Target modification pmrB pmrB 124 TCC S P Colistin 19332669 Target modification pmrB pmrB 130 AAT N Y Colistin 19332669 Target modification pmrB pmrB 147 ACC T P Colistin 19332669 Target modification pmrB pmrB 155 CGC R P Colistin 19332669 Target modification pmrB pmrB 156 ACG T P,M Colistin 19332669,19332669 Target modification pmrB pmrB 161 GTG V M,L,G Colistin 19332669,19332669,19332669 Target modification pmrB pmrB 166 GAA E K Colistin 19332669 Target modification pmrB pmrB 186 ATG M I Colistin 19332669 Target modification pmrB pmrB 206 GGG G W,R Colistin 19332669,19332669 Target modification pmrB pmrB 305 AGC S R Colistin 19332669 Target modification gyrA gyrA 67 GCC A P Nalidixic acid,Ciprofloxacin 7492118 Target modification gyrA_G81C.S.H.D gyrA gyrA 72 GAC D G Nalidixic acid,Ciprofloxacin 12409384 Target modification gyrA_S83Y.F.A gyrA gyrA 73 GTA V I Nalidixic acid,Ciprofloxacin 12409384 Target modification gyrA_S83Y.F.A gyrA gyrA 81 GGC G S Nalidixic acid,Ciprofloxacin 10471553;7492118;15153158 Target modification gyrA_A67P gyrA gyrA 81 GGC G C,H Nalidixic acid,Ciprofloxacin 10471553,7492118,15153158 Target modification gyrA gyrA 82 GAT D N Nalidixic acid 15215081 Target modification gyrA gyrA 82 GAT D G Nalidixic acid,Ciprofloxacin 12523636 Target modification gyrA gyrA 83 TCC S I Nalidixic acid,Ciprofloxacin 7492118;10471553 Target modification gyrA_D87K gyrA gyrA 83 TCC S Y,F,I Nalidixic acid,Ciprofloxacin 7492118,10471553 Target modification gyrA gyrA 87 GAC D K Nalidixic acid,Ciprofloxacin 12409384 Target modification gyrA_S83I gyrA gyrA 87 GAC D N,G,Y Nalidixic acid,Ciprofloxacin 10471553,11283069,7492118,15056435 Target modification gyrA gyrA 98 CTG L V Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A gyrA gyrA 119 GCA A E Nalidixic acid,Ciprofloxacin 12409384 Target modification gyrA gyrA 119 GCA A S Nalidixic acid,Ciprofloxacin 12409384 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K gyrA gyrA 119 GCA A V Nalidixic acid 8849216 Target modification gyrA gyrA 131 GCC A G Nalidixic acid,Ciprofloxacin 15848289 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K gyrA gyrA 139 GAA E A Nalidixic acid,Ciprofloxacin 15848289 Target modification gyrA_S83Y.F.A gyrB gyrB 421 TAC Y C Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K gyrB gyrB 426 GAC D N Nalidixic acid 3020376 Target modification gyrB gyrB 438 CGC R L Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K gyrB gyrB 447 AAA L E Nalidixic acid 3020376 Target modification gyrB gyrB 464 TCT S Y,F,T Ciprofloxacin 27896141,27896141,27896141 Target modification gyrB gyrB 466 GAA E D Nalidixic acid,Ciprofloxacin 26933021 Target modification parC parC 57 ACC T S Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parC parC 66 ACC T I Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parC parC 78 GGC G D Nalidixic acid,Ciprofloxacin 12705680 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parC parC 80 AGC S R,I Nalidixic acid,Ciprofloxacin 15388468,15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parC parC 84 GAA E K,G Nalidixic acid,Ciprofloxacin 14718091,27221661 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 438 ATG M I Nalidixic acid,Ciprofloxacin 26683630 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 454 GAA E G Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 458 TCG S P Nalidixic acid,Ciprofloxacin 14576119 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 462 CAT H Y Nalidixic acid,Ciprofloxacin 19104017 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 462 CAT H Y Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 499 GCT A T Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K parE parE 514 GTG V G Nalidixic acid,Ciprofloxacin 15388468 Target modification gyrA_S83Y.F.A;gyrA_D87N.G.Y.K acrB acrB 717 CGG R Q,L Azithromycin 31730615 Target modification 16S_rrsD 16S 1065 C C T Spectinomycin 12402084 Target modification 16S_rrsD 16S 1192 C C T Spectinomycin 12402084 Target modification