#Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut ompK36 ompK36 49 GAC D S cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 51 GAC D N cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 59 CTT L V cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 86 ACT T V cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 88 AGC S G cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 89 TCC S T cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 90 AGC S D cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 91 GAT D K cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 93 GCA A S cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 103 AAA K * carbapenem 22282462 Potential contribution to increased resistance ompK36 ompK36 183 GGC G D cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 183 GGC G S cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 184 GCG A M cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 184 GCG A P cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 189 GGC G T cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 190 GCT A W cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 191 CTG L Q cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 191 CTG L S cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 198 TTC F Y cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 200 ACT T L cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 207 TTC F W cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 207 TTC F Y cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 217 GCT A S carbapenem 25245001 Potential contribution to increased resistance ompK36 ompK36 218 AAC N H carbapenem 25245001 Potential contribution to increased resistance ompK36 ompK36 222 ACC T L cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 223 GAC D G cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 224 GAT D E cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 227 CAG Q N cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 227 CAG Q S cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 228 CTG L K cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 228 CTG L V cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 229 CTG L V cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 229 CTG L A cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 232 GAA E R cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 235 CAC H D cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 254 ACT T S cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompk36 260 GCT A V cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 304 AAC N E cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 354 AGC S N cephalosporins 25245001 Potential contribution to increased resistance acrR acrR 20 GCT A T fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 121 GGT G * tigecycline 27219271 Potential contribution to increased resistance acrR acrR 121 GGT G V tigecycline 27219271 Potential contribution to increased resistance acrR acrR 122 GAA E K tigecycline 27219271 Potential contribution to increased resistance acrR acrR 123 ATG M * tigecycline 27219271 Potential contribution to increased resistance acrR acrR 151 GCG A V fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 161 CCG P R fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 164 GGC G A fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 172 TTC F S fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 173 CGA R G fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 195 CTC L V fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 197 TTT F I fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 197 TTG L L fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 201 AAG K M fluoroquinolone 12936981 Potential contribution to increased resistance acrR acrR 204 TTC F L tigecycline 28533243 Potential contribution to increased resistance ramR ramR 19 GCG A V tigecycline 28533243 Potential contribution to increased resistance ramR ramR 44 CTG L R tigecycline 28533243 Potential contribution to increased resistance ramR ramR 103 CAC H Q tigecycline 27219271 Potential contribution to increased resistance ramR ramR 111 CTC L R tigecycline 28533243 Potential contribution to increased resistance ramR ramR 113 GAG E K tigecycline 28533243 Potential contribution to increased resistance ramR ramR 122 CAG Q * tigecycline 28533243 Potential contribution to increased resistance ramR ramR 135 CAG Q * tigecycline 28533243 Potential contribution to increased resistance ramR ramR 156 CTG L V tigecycline 27219271 Potential contribution to increased resistance ramR ramR 175 GAG E D tigecycline 27219271 Potential contribution to increased resistance ramR ramR 177 ATC I T tigecycline 27219271 Potential contribution to increased resistance ramR ramR 178 GCC A D tigecycline 27219271 Potential contribution to increased resistance ramR ramR 181 TTT F * tigecycline 27219271 Potential contribution to increased resistance ramR ramR 190 GAG E * tigecycline 27219271 Potential contribution to increased resistance ramR ramR 193 GCC A S tigecycline 27219271 Potential contribution to increased resistance ramR ramR 195 TGA * K tigecycline 28533243 Potential contribution to increased resistance ompK35 ompK35 174 CAG Q * carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 70 ATT I M carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 128 ATT I M carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 230 AAC N G carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 233 ATG M Q carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 234 ACC T H carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 235 CAG Q Y carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 237 AAC N H carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 239 CGC R K carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 244 GAA E D carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 274 AAT N S carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 275 GAC D T carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 277 GTG V I carbapenem 22282462 Potential contribution to increased resistance rpsL rpsL 43 AAG K T streptomycin unpublished Unconfirmed resistance phenotype rpsL rpsL 43 AAG K N streptomycin unpublished Unconfirmed resistance phenotype rpsL rpsL 43 AAG K R streptomycin unpublished Unconfirmed resistance phenotype rpsL rpsL 88 AAG K R streptomycin unpublished Unconfirmed resistance phenotype #Depends what is the original gyrB gyrB 359 TCT S A fluoroquinolone Unconfirmed resistance phenotype gyrB gyrB 359 TCC S A fluoroquinolone Unconfirmed resistance phenotype gyrB gyrB 359 TCG S A fluoroquinolone Unconfirmed resistance phenotype gyrB gyrB 359 TCA S A fluoroquinolone Unconfirmed resistance phenotype #gyrB gyrB 367 ? S T fluoroquinolone Unconfirmed resistance phenotype gyrA gyrA 83 TCC S L ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance gyrA gyrA 83 TCC S F ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance gyrA gyrA 83 TCC S Y ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance gyrA gyrA 83 TCC S I ciprofloxacin 30445211 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance gyrA gyrA 87 GAC D A ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance gyrA gyrA 87 GAC D N ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance gyrA gyrA 87 GAC D G ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance parC parC 80 AGC S I ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance parC parC 84 GAA E K ciprofloxacin 22633335 Target modification Combinations of gyrA-83 and other mutations normally need for high-level fluoroquinolone resistance #Indels ompK36 ompK36 393 - ins SG cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 393 - ins FGGD cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 552 - ins GAL cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 702 - ins L cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 702 - ins P cephalosporins 25245001 Potential contribution to increased resistance ompK36 ompK36 933 - ins R cephalosporins 25245001 Potential contribution to increased resistance acrR acrR 382 CAGGCCCAGCGCCAG del QAQRQ norfloxacin,ciprofloxacin 12936981 Potential contribution to increased resistance acrR acrR 432 ACCCTGAAAGAA del TLKE norfloxacin,ciprofloxacin 12936981 Potential contribution to increased resistance ompK37 ompK37 712 - ins TERY carbapenem 22282462 Potential contribution to increased resistance ompK37 ompK37 824 - ins SSTNGG carbapenem 22282462 Potential contribution to increased resistance