#Gene_ID Gene_name Codon_pos Ref_nuc Ref_codon Res_codon Resistance PMID Mechanism Notes Required_mut gyrA gyrA 70 GCC A T Nalidixic acid, Ciprofloxacin 8384814 Target modification gyrA gyrA 85 GAT D Y Nalidixic acid, Ciprofloxacin 18031331 Target modification Phenotype described only in association with other mutations (T86), unknown phenotype if the present mutation occurs alone gyrA_T86I.A.K.V gyrA gyrA 86 ACA T I,A,K,V Nalidixic acid, Ciprofloxacin 11266291,Unpublished,8384814,16713726 Target modification gyrA gyrA 90 GAT D A,N,T Nalidixic acid, Ciprofloxacin 8384814,8384814,16713726 Target modification gyrA gyrA 104 CCA P S Nalidixic acid, Ciprofloxacin 16713726 Target modification Phenotype described only in association with other mutations (R285), unknown phenotype if the present mutation occurs alone gyrA_R285K gyrA_2 gyrA_2 70 GCC A T Nalidixic acid, Ciprofloxacin 8384814 Target modification gyrA_2 gyrA_2 85 GAT D Y Nalidixic acid, Ciprofloxacin 18031331 Target modification Phenotype described only in association with other mutations (T86), unknown phenotype if the present mutation occurs alone gyrA_T86I.A.K.V gyrA_2 gyrA_2 86 ACA T I,A,K,V Nalidixic acid, Ciprofloxacin 11266291,Unpublished,8384814,16713726 Target modification gyrA_2 gyrA_2 90 GAT D A,N,T Nalidixic acid, Ciprofloxacin 8384814,8384814,16713726 Target modification gyrA_2 gyrA_2 104 CCA P S Nalidixic acid, Ciprofloxacin 16713726 Target modification Phenotype described only in association with other mutations (R285), unknown phenotype if the present mutation occurs alone gyrA_R285K 23S 23S 2074 A A G,T,C Azithromycin, Erythromycin, Clindamycin, Telithromycin 16713726,16713726,16713726 Target modification 23S 23S 2075 A A G Azithromycin, Erythromycin, Clindamycin, Telithromycin 16713726 Target modification rpsL rpsL 43 AAA K R Streptomycin 20370506 Target modification rpsL rpsL 88 AAA K R,E,Q Streptomycin 20370506 Target modification porA porA 56 GGT G D Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance porA porA 56 GGC G D Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance porA porA 56 GGA G D Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance porA porA 56 GGC G D Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeA cmeA 366 GCT A T Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeA cmeA 366 GCC A T Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeA cmeA 366 GCA A T Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeA cmeA 366 GCG A T Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeB cmeB 45 AAA K E Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeB cmeB 45 AAG K E Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeR cmeR 172 CCT P S Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeR cmeR 172 CCC P S Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeR cmeR 172 CCA P S Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance cmeR cmeR 172 CCG P S Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance # Indels porA porA 139 - ins ND Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance. The actual insertion is Asn139_Ala140insAsp, but is picked up by BLAST as N139_N139delinsND. porA porA 139 - ins D Ertapenem, Meropenem 37358443 Efflux Contributes to increased resistance