LOCUS       NC_003132               9612 bp    DNA     circular BCT 25-JAN-2008
DEFINITION  Yersinia pestis CO92 plasmid pPCP1, complete sequence.
ACCESSION   NC_003132
VERSION     NC_003132.1  GI:16082679
KEYWORDS    coagulase; fibrinolysin; IS100; omptin; pesticin; pesticin
            immunity; pim; pla; pst; rop; transcriptional regulator.
SOURCE      Yersinia pestis CO92
  ORGANISM  Yersinia pestis CO92
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
            Enterobacteriaceae; Yersinia.
REFERENCE   1  (bases 1 to 9612)
  AUTHORS   Parkhill,J., Wren,B.W., Thomson,N.R., Titball,R.W., Holden,M.T.,
            Prentice,M.B., Sebaihia,M., James,K.D., Churcher,C., Mungall,K.L.,
            Baker,S., Basham,D., Bentley,S.D., Brooks,K., Cerdeno-Tarraga,A.M.,
            Chillingworth,T., Cronin,A., Davies,R.M., Davis,P., Dougan,G.,
            Feltwell,T., Hamlin,N., Holroyd,S., Jagels,K., Karlyshev,A.V.,
            Leather,S., Moule,S., Oyston,P.C., Quail,M., Rutherford,K.,
            Simmonds,M., Skelton,J., Stevens,K., Whitehead,S. and Barrell,B.G.
  TITLE     Genome sequence of Yersinia pestis, the causative agent of plague
  JOURNAL   Nature 413 (6855), 523-527 (2001)
   PUBMED   11586360
REFERENCE   2  (bases 1 to 9612)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2004) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109969.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9612
                     /organism="Yersinia pestis CO92"
                     /mol_type="genomic DNA"
                     /strain="CO92"
                     /db_xref="taxon:214092"
                     /plasmid="pPCP1"
                     /biovar="Orientalis"
     misc_feature    1..9612
                     /note="REFSEQ gene predictions performed by GeneMark
                     2.4/GeneMark.hmm 2.0 with comparison to original submitter
                     provided annotation"
     repeat_region   1..1954
                     /mobile_element="insertion sequence:IS100"
     gene            87..1109
                     /locus_tag="YPPCP1.01"
                     /db_xref="GeneID:1172637"
     CDS             87..1109
                     /locus_tag="YPPCP1.01"
                     /note="probable IS100 transposase; similar to TR:P74993;
                     similar to TRA6_BACST putative transposase for insertion
                     sequence element IS5376; contains helix-turn-helix motif
                     from aa 19-40"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transposase"
                     /protein_id="NP_395227.1"
                     /db_xref="GI:16082680"
                     /db_xref="GeneID:1172637"
                     /translation="MVTFETVMEIKILHKQGMSSRAIARELGISRNTVKRYLQAKSEP
                     PKYTPRPAVASLLDEYRDYIRQRIADAHPYKIPATVIAREIRDQGYRGGMTILRAFIR
                     SLSVPQEQEPAVRFETEPGRQMQVDWGTMRNGRSPLHVFVAVLGYSRMLYIEFTDNMR
                     YDTLETCHRNAFRFFGGVPREVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGFS
                     PRLCRPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGITVDVETANRHGLRWLHDVA
                     NQRKHETIQARPCDRWLEEQQSMLALPPEKKEYDVHLDENLVNFDKHPLHHPLSIYDS
                     FCRGVA"
     gene            1106..1888
                     /locus_tag="YPPCP1.02"
                     /db_xref="GeneID:1172638"
     CDS             1106..1888
                     /locus_tag="YPPCP1.02"
                     /note="IS100 ATP-binding protein; similar to TR:P74994;
                     similar to ISTB_ECOLI insertion sequence IS21 putative
                     ATP-binding protein; contains PS00017 ATP/GTP-binding site
                     motif A; P-loop"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase/IS protein"
                     /protein_id="NP_395228.1"
                     /db_xref="GI:16082681"
                     /db_xref="GeneID:1172638"
                     /translation="MMMELQHQRLMALAGQLQLESLISAAPALSQQAVDQEWSYMDFL
                     EHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIER
                     NENIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQ
                     RGVMAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGD
                     AALTSAMLDRILHHSHVVQIKGESYRLRQKRKAGVIAEANPE"
     repeat_region   2265..2283
                     /note="rep"
     repeat_region   2321..2340
                     /note="rep"
     repeat_region   complement(2413..2432)
                     /note="rep"
     rep_origin      2924..4176
                     /note="similar to ColE1 ori"
     gene            2925..3119
                     /gene="rop"
                     /locus_tag="YPPCP1.03"
                     /db_xref="GeneID:1172639"
     CDS             2925..3119
                     /gene="rop"
                     /locus_tag="YPPCP1.03"
                     /note="plasmid replication regulatory protein; similar to
                     ROP_ECOLI regulatory protein ROP from ColE1; RNA one
                     modulator"
                     /codon_start=1
                     /transl_table=11
                     /product="putative replication regulatory protein"
                     /protein_id="NP_395229.1"
                     /db_xref="GI:16082682"
                     /db_xref="GeneID:1172639"
                     /translation="MNKQQQTALNMARFIRSQSLILLEKLDALDADEQAAMCERLHEL
                     AEELQNSIQARFEAESETGT"
     gene            4355..4780
                     /gene="pim"
                     /locus_tag="YPPCP1.04"
                     /db_xref="GeneID:1172640"
     CDS             4355..4780
                     /gene="pim"
                     /locus_tag="YPPCP1.04"
                     /note="pesticin immunity protein; similar to TR:Q57285
                     (EMBL:Z54145; X92856)"
                     /codon_start=1
                     /transl_table=11
                     /product="pesticin immunity protein"
                     /protein_id="NP_395230.1"
                     /db_xref="GI:16082683"
                     /db_xref="GeneID:1172640"
                     /translation="MISKLFCLALIFLSSSGLAEKNTYTAKDILQNLELNTFGNSLSH
                     GIYGKQTTFKQTEFTNIKSNTKKHIALINKDNSWMISLKILGIKRDEYTVCFEDFSLI
                     RPPTYVAIHPLLIKKVKSGNFIVVKEIKKSIPGCTVYYH"
     gene            complement(4815..5888)
                     /gene="pst"
                     /locus_tag="YPPCP1.05c"
                     /db_xref="GeneID:1172641"
     CDS             complement(4815..5888)
                     /gene="pst"
                     /locus_tag="YPPCP1.05c"
                     /note="similar to TR:Q57159 (EMBL:X92856)"
                     /codon_start=1
                     /transl_table=11
                     /product="pesticin"
                     /protein_id="NP_395231.1"
                     /db_xref="GI:16082684"
                     /db_xref="GeneID:1172641"
                     /translation="MSDTMVVNGSGGVPAFLFSGSTLSSYRPNFEANSITIALPHYVD
                     LPGRSNFKLMYIMGFPIDTEMEKDSEYSNKIRQESKISKTEGTVSYEQKITVETGQEK
                     DGVKVYRVMVLEGTIAESIEHLDKKENEDILNNNRNRIVLADNTVINFDNISQLKEFL
                     RRSVNIVDHDIFSSNGFEGFNPTSHFPSNPSSDYFNSTGVTFGSGVDLGQRSKQDLLN
                     DGVPQYIADRLDGYYMLRGKEAYDKVRTAPLTLSDNEAHLLSNIYIDKFSHKIEGLFN
                     DANIGLRFSDLPLRTRTALVSIGYQKGFKLSRTAPTVWNKVIAKDWNGLVNAFNNIVD
                     GMSDRRKREGALVQKDIDSGLLK"
     variation       5910
                     /note="as compared to sequence found in GenBank Accession
                     Number AF053945"
                     /replace=""
     variation       5927
                     /note="as compared to sequence found in GenBank Accession
                     Number AF053945"
                     /replace="aa"
     gene            6006..6422
                     /locus_tag="YPPCP1.06"
                     /db_xref="GeneID:1172642"
     CDS             6006..6422
                     /locus_tag="YPPCP1.06"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="NP_395232.1"
                     /db_xref="GI:16082685"
                     /db_xref="GeneID:1172642"
                     /translation="MKFHFCDLNHSYKNQEGKIRSRKTAPGNIRKKQKGDNVSKTKSG
                     RHRLSKTDKRLLAALVVAGYEERTARDLIQKHVYTLTQADLRHLVSEISNGVGQSQAY
                     DAIYQARRIRLARKYLSGKKPEGVEPREGQEREDLP"
     gene            6665..7603
                     /gene="pla"
                     /locus_tag="YPPCP1.07"
                     /db_xref="GeneID:1172643"
     CDS             6665..7603
                     /gene="pla"
                     /locus_tag="YPPCP1.07"
                     /EC_number="3.4.23.48"
                     /note="outer membrane protease; involved in virulence in
                     many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in
                     Escherichia coli OmpT can degrade antimicrobial peptides;
                     in Yersinia Pla activates plasminogen during infection; in
                     Shigella flexneria SopA cleaves t"
                     /codon_start=1
                     /transl_table=11
                     /product="outer membrane protease"
                     /protein_id="NP_395233.1"
                     /db_xref="GI:16082686"
                     /db_xref="GeneID:1172643"
                     /translation="MKKSSIVATIITILSGSANAASSQLIPNISPDSFTVAASTGMLS
                     GKSHEMLYDAETGRKISQLDWKIKNVAILKGDISWDPYSFLTLNARGWTSLASGSGNM
                     DDYDWMNENQSEWTDHSSHPATNVNHANEYDLNVKGWLLQDENYKAGITAGYQETRFS
                     WTATGGSYSYNNGAYTGNFPKGVRVIGYNQRFSMPYIGLAGQYRINDFELNALFKFSD
                     WVRAHDNDEHYMRDLTFREKTSGSRYYGTVINAGYYVTPNAKVFAEFTYSKYDEGKGG
                     TQTIDKNSGDSVSIGGDAAGISNKNYTVTAGLQYRF"
     gene            complement(7790..8089)
                     /locus_tag="YPPCP1.08c"
                     /db_xref="GeneID:1172644"
     CDS             complement(7790..8089)
                     /locus_tag="YPPCP1.08c"
                     /note="similar to predicted transcriptional regulator
                     TR:P95258 (EMBL:Z84498) Mycobacterium tuberculosis
                     MTCY09F9.0 8C (Rv1956); contains helix-turn-helix motif
                     from aa 42-63"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transcriptional regulator"
                     /protein_id="NP_395234.1"
                     /db_xref="GI:16082687"
                     /db_xref="GeneID:1172644"
                     /translation="MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQK
                     QVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMGGKLSLDVELPTGRRVAFHV"
     gene            complement(8089..8436)
                     /locus_tag="YPPCP1.09c"
                     /db_xref="GeneID:1172645"
     CDS             complement(8089..8436)
                     /locus_tag="YPPCP1.09c"
                     /note="similar to two hypothetical proteins from
                     Mycobacterium tuberculosis TR:O53468 (EMBL:O53468)
                     MTV018.09C (Rv2022c); similar to TR:O53332 (EMBL:AL021646)
                     MTV014.26 (Rv3182)"
                     /codon_start=1
                     /transl_table=11
                     /label=YPPCP1.09c
                     /product="hypothetical protein"
                     /protein_id="NP_395235.1"
                     /db_xref="GI:16082688"
                     /db_xref="GeneID:1172645"
                     /translation="MWMVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRPYA
                     DTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAIVLCAGDKSNDKRFYEKLVRIAE
                     DEFTAHLNTLESK"
     variation       8528..8529
                     /note="as compared to sequence found in GenBank Accession
                     Number AF053945"
                     /replace=""
ORIGIN      
        1 tgtaacgaac ggtgcaatag tgatccacac ccaacgcctg aaatcagatc cagggggtaa
       61 tctgctctcc tgattcagga gagtttatgg tcacttttga gacagttatg gaaattaaaa
      121 tcctgcacaa gcagggaatg agtagccggg cgattgccag agaactgggg atctcccgca
      181 ataccgttaa acgttatttg caggcaaaat ctgagccgcc aaaatatacg ccgcgacctg
      241 ctgttgcttc actcctggat gaataccggg attatattcg tcaacgcatc gccgatgctc
      301 atccttacaa aatcccggca acggtaatcg ctcgcgagat cagagaccag ggatatcgtg
      361 gcggaatgac cattctcagg gcattcattc gttctctctc ggttcctcag gagcaggagc
      421 ctgccgttcg gttcgaaact gaacccggac gacagatgca ggttgactgg ggcactatgc
      481 gtaatggtcg ctcaccgctt cacgtgttcg ttgctgttct cggatacagc cgaatgctgt
      541 acatcgaatt cactgacaat atgcgttatg acacgctgga gacctgccat cgtaatgcgt
      601 tccgcttctt tggtggtgtg ccgcgcgaag tgttgtatga caatatgaaa actgtggttc
      661 tgcaacgtga cgcatatcag accggtcagc accggttcca tccttcgctg tggcagttcg
      721 gcaaggagat gggcttctct ccccgactgt gtcgcccctt cagggcacag actaaaggta
      781 aggtggaacg gatggtgcag tacacccgta acagttttta catcccacta atgactcgcc
      841 tgcgcccgat ggggatcact gtcgatgttg aaacagccaa ccgccacggt ctgcgctggc
      901 tgcacgatgt cgctaaccaa cgaaagcatg aaacaatcca ggcccgtccc tgcgatcgct
      961 ggctcgaaga gcagcagtcc atgctggcac tgcctccgga gaaaaaagag tatgacgtgc
     1021 atcttgatga aaatctggtg aacttcgaca aacaccccct gcatcatcca ctctccatct
     1081 acgactcatt ctgcagagga gtggcgtgat gatggaactg caacatcaac gactgatggc
     1141 gctcgccggg cagttgcaac tggaaagcct tataagcgca gcgcctgcgc tgtcacaaca
     1201 ggcagtagac caggaatgga gttatatgga cttcctggag catctgcttc atgaagaaaa
     1261 actggcacgt catcaacgta aacaggcgat gtatacccga atggcagcct tcccggcggt
     1321 gaaaacgttc gaagagtatg acttcacatt cgccaccgga gcaccgcaga agcaactcca
     1381 gtcgttacgc tcactcagct tcatagaacg taatgaaaat atcgtattac tggggccatc
     1441 aggtgtgggg aaaacccatc tggcaatagc gatgggctat gaagcagtcc gtgcaggtat
     1501 caaagttcgc ttcacaacag cagcagatct gttacttcag ttatctacgg cacaacgtca
     1561 gggccgttat aaaacgacgc ttcagcgtgg agtaatggcc ccccgcctgc tcatcattga
     1621 tgaaataggc tatctgccgt tcagtcagga agaagcaaag ctgttcttcc aggtcatcgc
     1681 taaacgttac gaaaagagcg caatgatcct gacatccaat ctgccgttcg ggcagtggga
     1741 tcaaacgttc gccggtgatg cagcactgac ctcagcgatg ctggaccgta tcttacacca
     1801 ctcacatgtc gttcaaatca aaggagaaag ctatcgactc agacagaaac gaaaggccgg
     1861 ggttatagca gaagctaatc ctgagtaaaa cggtggatca atattgggcc gttggtggag
     1921 atataagtgg atcacttttc atccgtcgtt gacaccctga tgaattcacg tgttcacgcc
     1981 tgaataacaa gaatgccgga gatacgcagt catatttttt acacaattct ctaatcccga
     2041 caaggtcgta ggtcgttata ggaaaattct tagcaccatt ccggaacaat cagaacagca
     2101 ggccatgaac gactgacaac attacgaata taaaaaacgc acccgggcca gacattcccc
     2161 ctactgatta aaccagccgg acttgtccac ggaacggtct ttttaaaccg acacacagtc
     2221 tgagtacaga tacatgtcac gatgatgcag gattagcgga agagtgtgag cacgtttccg
     2281 ggaactgtgg tgaaccatag ctcaatattc gagtgagggc ataccggaaa cgcgctcaga
     2341 ttcgttgtaa cgcgattttc cgtaccgggc aattttttca gttgtttttt cgtttcatgt
     2401 cgtcagaaac gttctgagcg cgtttccggc atctgatgct acgcaaacca tccccatggt
     2461 cagttgacag ccggaaacac gcgggtgtcg ttttagcgta tcgacgggac ggcgtcgaga
     2521 agcacaaaaa acagatgttg tactcagtca gttgttttac agacagcact gcggcagatt
     2581 gaaaaagtac cgtactttca ggaatgtcca gaaaccatgt gtcagacttc gttctccccc
     2641 ttccgggtga atttttttgt catccgttca ggaatctctt tataacgatt actccatttc
     2701 aggatttttt atgtggcgtt tactacaggc aggatattca aaggcaaaaa aatcccccgg
     2761 aacaggcgga acccggacag ggggagaacg aatcgctaaa taattttcgt agttgtattt
     2821 cccatcgttg ctactgcaac gggatgaatt tgccgcagtt tatcctgtaa aacaatcctg
     2881 atttactcac actccacata tcactgacgg agcacaacgg aatagtgaac aaacaacaac
     2941 aaactgcgct gaatatggcg cgatttatca gaagccagag cctgatactg cttgaaaaac
     3001 tggatgctct ggatgccgac gagcaggcgg ccatgtgtga acgactgcac gaactcgcgg
     3061 aagaactcca gaacagcatc caggctcgct ttgaagccga aagtgaaaca ggaacataac
     3121 gaagctcccg gagacggtca cagcttgtct gtgaacggat gccgggagca gacaagcccg
     3181 tcagggcgcg tcagcgggtt ttagcgggtg tcggggcgca gccatgaccc agtcacgtag
     3241 cgatagcgga gtgtatactg gcttagtcat gcggcatcag tgcggattgt atgaaaagtg
     3301 caccatgtac ggtgtgaaat gccgcacaga tgcgtaagga gaacatgcag atgccgatgc
     3361 tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggtg
     3421 tctgctcact caaaagcggt gatactgtta tccacacaat caggggataa cgccggaaag
     3481 aacatgtgag caaaaaacga agaccccaga aaaggccgcg ccggaggcgc tttttccata
     3541 ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc
     3601 cgacaggact taaagatacc aggcgtttcc ccccggaagc tccctcgtgc gctctcctgt
     3661 tccgaccctg ccgcttaccg gatacctctc cgcctttctc ccttcgggaa gcgtggcgct
     3721 ttctcatagc tcacgctgtt ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg
     3781 ctgtgtgcac gaaccccccg ttcagcccga ccactgcgcc ttatccggta actatcgtct
     3841 tgagtccaac ccggtaagac acgactttac gccactggca gcagccattg gtaactgaaa
     3901 agtggattta gatacgcaga actcttgaag ttgaagcctt atcgcggcta cactgaaagg
     3961 acagcatttg gtatctgtgc tccacttaag ccagctacca caggttagaa agcctgagaa
     4021 acttctaacc ttcgaaagaa cccacgcctg agaacgtggg ttttttcgtt tacaggcagc
     4081 agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct actgaattgc
     4141 gctcccgatc agttcagcag aagattatga tggggttcta tgggtattgc tgcggtaaca
     4201 cccatgttac ttgaggttgt atgtagtctg tgtagaatta tacacataag gcttaaactg
     4261 ctcttttttt tcaatatgca attggaagtt cattgactac ataaatagat tattccaaat
     4321 aatttattta tgtaagaaca ggatgggagg gggaatgatc tcaaagttat tttgcttggc
     4381 tctcatattt ttatcatcaa gtggccttgc agaaaaaaac acatatacag caaaagacat
     4441 cttgcaaaac ctagaattaa atacctttgg caattcattg tctcatggca tctatgggaa
     4501 acagacaacc ttcaagcaaa ccgagtttac aaatattaaa agcaacacca aaaaacacat
     4561 tgcacttatc aataaagaca actcatggat gatatcatta aaaatactag gaattaagag
     4621 agatgagtat actgtctgtt ttgaagattt ctctctaata agaccgccaa catatgtagc
     4681 catacatcct ctacttataa aaaaagtaaa atctggaaac tttatagtag tgaaagaaat
     4741 aaagaaatct atccctggtt gcactgtata ttatcattaa tagcaagccc ctcattatta
     4801 tgaggggctc atggttattt taacaatcca ctatcgatat ctttttgcac cagagcgccc
     4861 tctcgtttac gtctgtcaga cattccatca acaatattat taaaagcatt tacaaggcca
     4921 ttccagtctt ttgcgataac tttattccat actgtgggag cagttctgga taacttaaac
     4981 cctttttgat atccaataga caccagtgct gtacgggttc tcaacggtaa atcgctgaac
     5041 cgaagaccga tattagcgtc attgaaaaga ccttcaatct tatgtgagaa tttatcaata
     5101 taaatattag ataagagatg agcttcatta tcagaaagcg tcagaggtgc tgttctcact
     5161 ttatcataag cctccttccc tcgaagcata taatacccat caagtctatc tgcaatatac
     5221 tgagggacac cgtcattcaa taaatcctgt ttgcttcgct gaccaaggtc aaccccggaa
     5281 ccgaatgtaa caccggtact gttaaaataa tcgctactag gattagacgg aaaatgactt
     5341 gtcggattaa acccttcaaa accattactg gagaaaatat cgtggtcaac aatatttacc
     5401 gaacgacgta aaaattcctt cagttgacta atattgtcaa agttaatgac agtgttgtcc
     5461 gctaggacga tgcgatttcg gttattattc agaatgtctt cgttctcttt cttatcgaga
     5521 tgttcaatag attcggcaat cgttccctca agaaccatga cacggtagac tttcacaccg
     5581 tctttttcct gacctgtttc aacagttatt ttctgttcgt aagacacggt cccttcagtt
     5641 tttgaaattt tactttcctg gcggatctta tttgaatatt cactgtcttt ctccatctcc
     5701 gtatcaatcg gaaaccccat aatgtacatc agtttaaaat tactccggcc aggcagatcc
     5761 acataatgtg gtaatgcaat tgtaatcgaa ttagcttcaa aatttggtct gtaactgctt
     5821 aatgtacttc cggaaaagag aaaagccgga acaccacctg aaccattcac taccattgta
     5881 tctgacataa aaattcctct ttaacacata aaaaaaacaa taagttaaaa aaaatactgt
     5941 acataaaacc actgttttta tgtacagtaa taaaattacg ccgctttatt ttctctgtca
     6001 ataatatgaa atttcatttt tgtgatctga atcactctta taaaaatcag gaagggaaga
     6061 ttcgcagcag aaaaacagca ccgggtaaca tcagaaaaaa acagaaagga gataacgtga
     6121 gcaaaacaaa atctggtcgc caccgactga gcaaaacaga caaacgcctg ctggctgcac
     6181 ttgtcgttgc cggatacgaa gaacggacag cccgtgacct catccagaaa cacgtttaca
     6241 cactgacaca ggccgacctg cgccatctgg tcagtgaaat cagtaacggt gtgggacagt
     6301 cacaggccta cgatgcgatt taccaggcga gacgcattcg tctcgcccgt aaatacctga
     6361 gcggaaaaaa accggaaggg gtggaacccc gggaagggca ggaacgggaa gatttaccat
     6421 aactcccgtt atcagtacca tcggctcaac gctcgttgtc ggatctgaaa aattcgctca
     6481 aaagatcata tttccctgga tattttccac cgtttcttat gtgagcaaag tcacataatt
     6541 ctgtcagacg acgagaaaac ggatatcgat tattgtttaa tatttttaca ttattaaaaa
     6601 tgaaattaga taatcagata caaataatat gttttcgttc atgcagagag attaagggtg
     6661 tctaatgaag aaaagttcta ttgtggcaac cattataact attctgtccg ggagtgctaa
     6721 tgcagcatca tctcagttaa taccaaatat atcccctgac agctttacag ttgcagcctc
     6781 caccgggatg ctgagtggaa agtctcatga aatgctttat gacgcagaaa caggaagaaa
     6841 gatcagccag ttagactgga agatcaaaaa tgtcgctatc ctgaaaggtg atatatcctg
     6901 ggatccatac tcatttctga ccctgaatgc cagggggtgg acgtctctgg cttccgggtc
     6961 aggtaatatg gatgactacg actggatgaa tgaaaatcaa tctgagtgga cagatcactc
     7021 atctcatcct gctacaaatg ttaatcatgc caatgaatat gacctcaatg tgaaaggctg
     7081 gttactccag gatgagaatt ataaagcagg tataacagca ggatatcagg aaacacgttt
     7141 cagttggaca gctacaggtg gttcatatag ttataataat ggagcttata ccggaaactt
     7201 cccgaaagga gtgcgggtaa taggttataa ccagcgcttt tctatgccat atattggact
     7261 tgcaggccag tatcgcatta atgattttga gttaaatgca ttatttaaat tcagcgactg
     7321 ggttcgggca catgataatg atgagcacta tatgagagat cttactttcc gtgagaagac
     7381 atccggctca cgttattatg gtaccgtaat taacgctgga tattatgtca cacctaatgc
     7441 caaagtcttt gcggaattta catacagtaa atatgatgag ggcaaaggag gtactcagac
     7501 cattgataag aatagtggag attctgtctc tattggcgga gatgctgccg gtatttccaa
     7561 taaaaattat actgtgacgg cgggtctgca atatcgcttc tgaaaaatac agatcatatc
     7621 tctcttttca tcctccccta gcggggagga tgtctgtgga aaggaggttg gtgtttgacc
     7681 aaccttcaga tgtgtgaaaa atcacctttt tcaccataat gacggggcgc tcattctgtt
     7741 gttttgcctt gacattctcc acgtctttca gggcatggag aaggtcaaat tagacatgga
     7801 acgctactct ccttcctgta ggaagctcaa catccaagct taatttgcct cccattgctt
     7861 caacgtaacg ctttaacgtc gccagcttta aatcatttcc gcgctgctcc agctttgtta
     7921 ctgctggctg gcttataccc atcgcctcag caacttgttt ttgtgataac tggagttctt
     7981 cacgcatcat ctgcaagccg acctcaagaa tcatctcatc tgccatttct ttaattcgtg
     8041 tctggctttc aggtgaacga ctggcaatca cctcatctaa tgttctcatt acttgctctc
     8101 cagtgtgttc agatgtgctg taaattcatc ctcagctata cgcaccagtt tttcataaaa
     8161 ccgcttatca ttacttttat ctcctgcaca aagaacgata gcccgacgaa tcggatcgaa
     8221 cgcataaaag gctcttatcg gacggccaga aaactgaacg cgaagctctt tcatattttt
     8281 gtaccgagaa cctttcacgg tatcggcata tggcctgggt aactcaggtc cgtaaacctg
     8341 tagctttttc aaatcagcca aaaccttttc ctgaagagcg tcttcttgct catttagcca
     8401 gtcgtcaaat cgctggctaa aaagtaccat ccacatgctc aaccctataa cctgtagctt
     8461 accccactaa caatataacc tacgagttat attttcaaga aaagctggct atttaacata
     8521 acggcaattt ttgtacgcac cactgaaatg cgttcagcgc gatcacggca acagacaggc
     8581 aaaaatagca acaaacctcc cgaaaaaccg ccgcgatcgc gcctgataaa ttttaacctt
     8641 atgcatatct atgcagccag gcgaatcacg aacgaattgc ctgcctgatg taactgaaac
     8701 gggtgttttt tcctgatttg gtgggcgtgg aagacggaac atgaacggga aaacagaatt
     8761 catgccagat gagcgcgatc tggcaattaa ggcaaaacac agcaacaaag acacgccaga
     8821 atcgcgcccg gatatgtttt aacgcgattt tcagactcag acaaattcag cagaatgcta
     8881 ctccattcac cgggctgatg gtgaatacat gcgtatccag gatgagtaca tttctggctc
     8941 tgccacagct ctgtctgttg gcagctttcg cctgtccgga aacctgctta aaacgctccc
     9001 gaaaggcctc tgaaccagaa agcaacaaaa cacaggccat taagtaaatc gcgttaaaac
     9061 acgtctgatg gattgctgca aaaaaaagtc cctaatggag cagggactgt taaacccagt
     9121 gaatagcgtc taaattaaag taagaatacg accaggtact cttcagaaaa gagattaatc
     9181 caccgcacag aataatcaac agtaaaaaca aacaaccctg attttttatt tttctttttt
     9241 tcgataaaaa caaaattaaa gaaataatta atcagaacat tccttaactt cagggcattg
     9301 cctgtgttcc attttgtgat tagtctgaaa cttccgaagg tggataacac ccggtatttt
     9361 tttgctcaca taaagcccct ccttcaggca gaggggcttt ttctttgcca ccacataaaa
     9421 aaggccctca caggaggtgt tctgtgaggg cgtatgataa ggactgaatc gatggttaat
     9481 atgtctagtc ctgacttttg catctccgaa tataaaaccc tgtttaacgg catgcaaaac
     9541 caaaaaataa aaatgtgaca tcgcaatgcc agataatatt gacgcatgag ggaatgcgta
     9601 ccccgacccc tg
//
