LOCUS       NC_008498              13413 bp    DNA     circular BCT 31-OCT-2006
DEFINITION  Lactobacillus brevis ATCC 367 plasmid 1, complete sequence.
ACCESSION   NC_008498
VERSION     NC_008498.1  GI:116334867
KEYWORDS    .
SOURCE      Lactobacillus brevis ATCC 367
  ORGANISM  Lactobacillus brevis ATCC 367
            Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae;
            Lactobacillus.
REFERENCE   1  (bases 1 to 13413)
  AUTHORS   Makarova,K., Slesarev,A., Wolf,Y., Sorokin,A., Mirkin,B.,
            Koonin,E., Pavolv,A., Pavlova,N., Karamychev,V., Polouchine,N.,
            Shakhova,V., Grigoriev,I., Lou,Y., Rohksar,D., Lucas,S., Huang,K.,
            Goldstein,D.M., Hawkins,T., Plengvidhya,V., Welker,D., Hughes,J.,
            Goh,Y., Benson,A., Baldwin,K., Lee,J.-H., Diaz-Muniz,I., Dosti,B.,
            Smeianov,V., Wechter,W., Barabote,R., Lorca,G., Altermann,E.,
            Barrangou,R., Ganesan,B., Xie,Y., Rawsthorne,H., Tamir,D.,
            Parker,C., Breidt,F., Broadbent,J., Hutkins,R., O'Sulllivan,D.,
            Steele,J., Unlu,G., Saier,M., Klaenhammer,T., Richardson,P.,
            Kozyavkin,S., Weimer,B. and Mills,D.
  TITLE     Comparative genomics of the lactic acid bacteria
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (42), 15611-15616 (2006)
   PUBMED   17030793
REFERENCE   2  (bases 1 to 13413)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2006) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 13413)
  AUTHORS   Lucas,S., Copeland,A., Detter,J.C., Glavina del Rio,T., Pitluck,S.,
            Grigoriev,I., Rokhsar,D., Slesarev,A., Pavlov,A., Pavlova,N.,
            Karamychev,V., Polouchine,N., Shakhova,V., Kozyavkin,S.,
            Makarova,K., Koonin,E., Mills,D.A. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute (JGI), The Lactic Acid Bacteria
            Genome Consortium and Fidelity Systems Inc.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAY-2006) US DOE Joint Genome Institute, 2800
            Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CP000417.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 2662178
            Source DNA and bacteria available from Milton Saier
            (msaier@ucsd.edu)
            Bacteria also available from ATCC: ATCC 367
            Contacts: Milton Saier (msaier@ucsd.edu)
                      Paul Richardson (microbes@cuba.jgi-psf.org)
            Annotation done by Kira Makarova and Eugene Koonin
            Finishing done by Fidelity Systems Inc. (Gaithersburg)URL --
            http://www.fidelitysystems.com
            Project Information available at:
            http://genome.jgi-psf.org/mic_home.html
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..13413
                     /organism="Lactobacillus brevis ATCC 367"
                     /mol_type="genomic DNA"
                     /strain="ATCC 367"
                     /db_xref="ATCC:367"
                     /db_xref="taxon:387344"
                     /plasmid="1"
     gene            complement(352..1281)
                     /locus_tag="LVIS_A01"
                     /db_xref="GeneID:4414791"
     CDS             complement(352..1281)
                     /locus_tag="LVIS_A01"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_796394.1"
                     /db_xref="GI:116334868"
                     /db_xref="GeneID:4414791"
                     /translation="MKEKNSNYNRFMAETQVTWEHYERVRKCFGNVGSFAYWPERDSS
                     STQIPGKGKRAIKYKALPIIAHNESEYIAKKLNKHLHNGVVLLGLNFGVPKDCLGFTE
                     FEKIEALRSMNDMSNQYGGKYGRKSLNVYLNEDYYSNVENVVGDPIGYDEVVCRYTEG
                     AYMTDFFKYSIETKLDNKKSACSKPTGMPSTDGEKLLKQYRKEEFEHLIEVNAKGLKK
                     ELDALGTPDNVIIAPMSARLRDKDVEDAICKCLERNVKFINCLEHYQSRSGNKPEKDK
                     CIKHPLQARFARNLIKANEGIEKIVQERLSEQN"
     gene            complement(1613..2449)
                     /locus_tag="LVIS_A02"
                     /note="LactoCOG number LaCOG03195"
                     /db_xref="GeneID:4414792"
     CDS             complement(1613..2449)
                     /locus_tag="LVIS_A02"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_796395.1"
                     /db_xref="GI:116334869"
                     /db_xref="GeneID:4414792"
                     /translation="MSKYKRNFQEVNEQWNDQINFIQESIRAFDNGNEKEARRLATAI
                     RVMFHDSRESLSIYNQLIKWSGKDMIFKSITDIYSPANLISSWLQLALQQSKNGLRYI
                     PNLDESVNRRIFFMNFDDWWNQIIFDDKKNCFTRRDVVLFVANKDGGAHLDSEIKESY
                     ANIVKYNSIGWTDSDGKSPSNNPLYTSIRVISQEILDSIKLNLYSPHRVTYINKGHEM
                     EMRFVKQGEKKRYPWSSTEVQKSPETQSIVDKHQKKSRTLYIREYQGENEGKIRVEYI
                     GK"
     gene            complement(3023..3307)
                     /locus_tag="LVIS_A03"
                     /note="LactoCOG number LaCOG03281"
                     /db_xref="GeneID:4414793"
     CDS             complement(3023..3307)
                     /locus_tag="LVIS_A03"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-damage-inducible protein J"
                     /protein_id="YP_796396.1"
                     /db_xref="GI:116334870"
                     /db_xref="GeneID:4414793"
                     /translation="MARIEARIDGTIKSKAKDVLAEHGLTISDFMRMTLTTVANEGLP
                     KYYSIPNRQLKDSIQEVIDDLSGKEKLPEAHSLKELDQLLSSDDALESSK"
     gene            3440..5071
                     /locus_tag="LVIS_A04"
                     /note="LactoCOG number LaCOG03161"
                     /db_xref="GeneID:4414794"
     CDS             3440..5071
                     /locus_tag="LVIS_A04"
                     /codon_start=1
                     /transl_table=11
                     /product="Type IV secretory pathway, VirD4 component"
                     /protein_id="YP_796397.1"
                     /db_xref="GI:116334871"
                     /db_xref="GeneID:4414794"
                     /translation="MIDLIVLVLLILLAIYAHKKHAAGEKLITKPLRFFIFPVHWWLR
                     NAIFKFTGSNFITGIIWFFAGIFIFLLFIPVYVINKTAGFIFAYYLAFGYFFCLFPQN
                     TALAGDSDLGRAKYLSYSELKHGGLITNTGLVLGKKQHRLVAKPSDFEGNVAVFGGAG
                     TGKTAGNLIPTLLTFQGNALVVDIKPELLKRTGHLHPNKEVLNFINPKQSYDPLATLQ
                     TYTDVTDLAKTLIPISSDIKEPYFRESAQNILASACWEFKGQKSFSEIAEFLTATPAD
                     AIIKQLSASSKSETRILINAVAGIKTEQLASVMNELRNTLVIFATDPVLKQLAGHSAN
                     SIQPQDIETNWIYLVLPESKLKVYQPYLALIVAQFTRYLTQRPEKSQPNLLLALDEFP
                     RLGYLPAFADAISTLRSRNVSVMILLQSLAQLDQLYQETGRKIIMDNMHYVVVHNALD
                     HTSQQYFSDRAGTKTAVAKSHSYGTGGSGGTIDALFGSSSTSYNQQSAPLIRPEEFAT
                     LKQPILYAYQLGITPVDKAYWFEDNHMKSMVELND"
     gene            5144..5467
                     /locus_tag="LVIS_A05"
                     /db_xref="GeneID:4414795"
     CDS             5144..5467
                     /locus_tag="LVIS_A05"
                     /codon_start=1
                     /transl_table=11
                     /product="Plasmid maintenance system killer protein"
                     /protein_id="YP_796398.1"
                     /db_xref="GI:116334872"
                     /db_xref="GeneID:4414795"
                     /translation="MEYVAENRKLAKILNDPRLLVKNFGRDRAKRIQSRLDEFDAADT
                     LQQIPSDPPPRCHRLHNNLEGKFAVDVSKNFRIVFEGYDKSDQLSVEKSAIVTVQILK
                     IEDYH"
     gene            5481..5816
                     /locus_tag="LVIS_A06"
                     /note="LactoCOG number LaCOG01493"
                     /db_xref="GeneID:4414796"
     CDS             5481..5816
                     /locus_tag="LVIS_A06"
                     /codon_start=1
                     /transl_table=11
                     /product="Transcriptional regulator, xre family"
                     /protein_id="YP_796399.1"
                     /db_xref="GI:116334873"
                     /db_xref="GeneID:4414796"
                     /translation="MLHRENSIRQYHTSSAADLIKETMDFYQITQTDLAARLGVSQKN
                     ISDILKRKRFINELLALRIETVMGISSQLLLNLDANFKLHQAKENAKNSEPDHQSDKF
                     LKRYDWVSA"
     gene            6654..7823
                     /locus_tag="LVIS_A07"
                     /db_xref="GeneID:4414797"
     CDS             6654..7823
                     /locus_tag="LVIS_A07"
                     /codon_start=1
                     /transl_table=11
                     /product="Relaxase/Mobilisation nuclease domain"
                     /protein_id="YP_796400.1"
                     /db_xref="GI:116334874"
                     /db_xref="GeneID:4414797"
                     /translation="MATTHIKRSTSASRLVNYAEKRAVKKDGLNLDIQYAKSELKQVR
                     DVYGNPGKTQAYASRIAFSPLEFNPKDPHDQATVLAVAKEIYAQAYPNQQVALYEHAD
                     TDSLHVHAVIGAINLETGQKLHGNWHQYRDHLVHITDQVCWEHGLMVTKPDPNRHEKR
                     TMAEIKLRAKQQPTWKDQIRQAVDHTMQNPLIRDFQAFQSDLKQQAVKVWQRGKNLTY
                     QLLGTNYKSRGTKLGLDYEKETIFNELARRQFQSKNNQQPQRAVNATNEPAQSNPDRT
                     PQLPGHPDSTASHGQNVVGSTTPADRTDCSTGQSPVSDDLKQLRRQQQQLTGPIKTDL
                     TKRLRSLSKADQPNQSAKSDRTQTDPNRARPKQSAPQPTRRPSEPDHSRNDGPSR"
     gene            7381..7959
                     /locus_tag="LVIS_A08"
                     /pseudo
                     /db_xref="GeneID:4414798"
     gene            complement(8193..9302)
                     /locus_tag="LVIS_A09"
                     /note="LactoCOG number LaCOG03083"
                     /db_xref="GeneID:4414799"
     CDS             complement(8193..9302)
                     /locus_tag="LVIS_A09"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_796401.1"
                     /db_xref="GI:116334875"
                     /db_xref="GeneID:4414799"
                     /translation="MDQANFKFYQADNVYRALFFQFPKVLMYGQQYRKLSDTAKLAYM
                     VLKDRLEYSLRNHWVDEEGHIYFIFTNQELKDLFNCSNDKLANVKKELENAGLLYQKA
                     MHFNPKTGKNEPNRLYLAELDMQPTDVYLRGEYAQKEPQTLATSENPKIGRSQETVET
                     LATSENPKIGRSRKFVDDTPQTLATSENPKIGHNLYKDFKNIDTNRYNIDTQKLDFST
                     TNFSSSEIEQQNQDLVKHANEFLTDKDGGLPVFLEPKAVQLLSFWCRTPQQMRRFIGI
                     ILNAKYRVEKDHQDIGVLIPLDDPELQPLMTKTLRRYFNALRSNEKQIKDVENYLYGT
                     MQNLFANYWNKKAARRYYDEHPGEEKPADNSWLYY"
     gene            9977..10564
                     /locus_tag="LVIS_A10"
                     /db_xref="GeneID:4414800"
     CDS             9977..10564
                     /locus_tag="LVIS_A10"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_796402.1"
                     /db_xref="GI:116334876"
                     /db_xref="GeneID:4414800"
                     /translation="MGKTIRQLSEELQLSKQAINQRISSIKDFRSKHTHKVKNHLEID
                     EQGVKMLANFDKQKRQDQQVNRQERQAENDKQDKKQTNINDVLLKQLDVKDQQISKLQ
                     KSLDQQQQLQLATLAENRQLKGHIQKLNGLLESSNSTQKRQATKKNDNLPNSVKPHNI
                     KDKNDKQDRNSVVGAGKMQRKIHKNKTNKSWWHFW"
     gene            11198..11962
                     /locus_tag="LVIS_A11"
                     /note="LactoCOG number LaCOG00006"
                     /db_xref="GeneID:4414801"
     CDS             11198..11962
                     /locus_tag="LVIS_A11"
                     /codon_start=1
                     /transl_table=11
                     /product="Transcriptional regulator, xre family"
                     /protein_id="YP_796403.1"
                     /db_xref="GI:116334877"
                     /db_xref="GeneID:4414801"
                     /translation="MSFKEDIKTLRRQSNLTQEALAQQLHVTRQTVSTWETGKNMPNL
                     ETLHALSQLFNISLEKLLFNEEITMKKDKDPSLATQIDHDVKLKSRYRRWTFGLGGLI
                     ALALVSIGILCLGYYKGIGTIDRFDPFLSYKVGYTKLPSEKEISPNNKATNGYWTAWF
                     TDNTMGNEWTKLTLTTGLNPGVKNPYVMAYHKGSYVKVARIVPRTYINQTYVSNLAAL
                     DALLNHKGNTATNNHDLKKYKTQIHISDTVQQLVTE"
     gene            12101..12706
                     /locus_tag="LVIS_A12"
                     /note="LactoCOG number LaCOG00006"
                     /db_xref="GeneID:4414802"
     CDS             12101..12706
                     /locus_tag="LVIS_A12"
                     /codon_start=1
                     /transl_table=11
                     /product="Transcriptional regulator, xre family"
                     /protein_id="YP_796404.1"
                     /db_xref="GI:116334878"
                     /db_xref="GeneID:4414802"
                     /translation="MKFGDRLKKGRTELNLTQEQVARDFFITRQTISSWENEKTYPDI
                     ISLIKLSDYYHVSLDTLLKEDTGMREFLEKKDVTRKIKPIYRNLIVIDLLVCSLLLGD
                     FFNLIHLGVFILPIFLLLLCSVSALNKLNAFNNSSSLGLKYTWQKYLSGEKGLKYSLV
                     MPTLFIISGVAFLLLKELYIGGIIIIAGALLIFFIFTQKKD"
ORIGIN      
        1 atgattcccc tcctcaactt atctaatatt ataggcgtac atgatagcgt acgtcaatta
       61 caaactatta tatcgtcaaa ggagattatg acttatgcaa caaatcgtcc tacccatcaa
      121 agactctaac gttctcaaag aggtccaaga caccttactt cataatttta aagctggttg
      181 tcgcaactat acgatttttc aagttggcaa ggccacctta ttacgaatga gcgatgttat
      241 gcggctccgt tggactgatg tctttaacga aaacggaacc gtgcgttaga atacgtttat
      301 ccacacccta tcgcatacga aatgacagtt gtacaatgtt ttacaaggat tttagttctg
      361 ctcagaaagg cgctcttgca ctattttctc aatcccttcg tttgccttga ttaagtttct
      421 agcaaatctc gcctgcagtg gatgcttgat acacttgtct ttctcaggtt tattgccgga
      481 acgggactga taatgttcta agcaattaat aaattttacg tttctttcga ggcacttgca
      541 tattgcgtcc tcgacatcct tatctcttaa tctggcactc atgggtgcaa tgataacatt
      601 atcaggcgtg cctaaggcat caagttcttt ctttaagcct ttggcattca cctctatcaa
      661 gtgttcaaat tcctctttac ggtactgttt cagtaacttt tcaccatcag tcgaaggcat
      721 tccagtgggc tttgaacagg cacttttttt gttgtcaagt ttggtctcga tactatactt
      781 aaagaagtct gtcatgtaag cgccctctgt ataacgacaa actacttcat catagcctat
      841 tggatcacca acaacattct caacgttgct ataatagtct tcgtttaaat acacattcaa
      901 tgattttcgc ccatatttac caccatattg gttagacata tcattcatgc ttctaagtgc
      961 ttcaatcttt tcaaactctg tgaatccaag gcagtctttt ggcactccaa aattcaaccc
     1021 aagcaacaca accccattat gtaaatgttt atttagtttt ttagctatat attcagactc
     1081 attatgcgca ataatcggca aggctttata cttaatagca cgcttacctt ttcctggaat
     1141 ttgtgtactg ctggaatctc tttcgggcca ataggcaaag cttccaacgt tgccgaagca
     1201 tttccgtact cgttcataat gttcccacgt tacttgggtc tcagccatga acctattgta
     1261 gttgctgttc ttctccttca ttatatttct ccttatcctt tgtagcttta ttaaaacatt
     1321 gcttatgttt gtatggataa cgcggttaat taaatcatta atcccttcgt attgcttatt
     1381 atgcgcttaa gtcaataatg ttttgtcgtt ctaatgtaat gttcctacta ttgatacatt
     1441 ctatatacgt gaaaccgatt tgactattag aaatatagag attgcaactt agaacgagat
     1501 tttgatagta cgagcgtgcc taatacagga atactttgta tcgatcagca ttcaaagtcc
     1561 gtccaaaaaa tcacaccttc gcggatcaca caaacaaaag tttctattac tcttattttc
     1621 caatatattc aactctaatt ttgccttcat tttcaccttg atattctcta atataaagtg
     1681 tccgtgattt tttttgatgt ttatcaacaa tgctttgagt ttcaggtgat ttttggactt
     1741 cagtgctaga ccacggatat ctttttttct ctccctgctt cacaaacctc atttccattt
     1801 cgtgtccctt atttatatag gtcactcggt ggggactata aagattcagc ttgatcgagt
     1861 cgagtatttc ttgagaaatc actctaatgg atgtataaag tggattatta gaaggggatt
     1921 taccgtcact gtccgtccaa ccaatagaat tatatttaac tatattcgcg taggattctt
     1981 taatttctga atcaagatgg gctcccccat ccttattagc cacaaaaagg actacatctc
     2041 ttctcgtaaa acaatttttc ttatcatcaa aaattatttg gttccaccaa tcatcaaaat
     2101 tcataaaaaa gatccttcta tttacacttt catccaagtt tggaatgtac cttaacccat
     2161 tcttactttg ttgtaatgct aattgcaacc atgaagaaat caagtttgct ggtgaataaa
     2221 tatctgtgat agatttaaaa atcatgtctt tccctgacca cttaataagc tgattataaa
     2281 tagacaaaga ctctctcgaa tcatgaaaca tcacacgaat cgcagttgca agtcttctag
     2341 cttctttctc attgccgtta tcaaatgcac gaatcgattc ctgtataaaa ttaatctggt
     2401 cattccattg ctcattaact tcttgaaagt ttcttttata ttttgacatg ctcaaaccgc
     2461 cctttcacta gtcctagtgc atactttctt ctctgacttc attttagtat atttggggca
     2521 aaaatggggg attaagcgca tgaatcactt caaaggacgt cactttcaaa gagacatcat
     2581 cttagccgcc gttggatacc attttagatt cagtctcagc tatcgtgata tcgtcgaatt
     2641 gcttcgggat caaagcatga ccgttcatca caccacggtc atgcgatggg tccatcacta
     2701 tggccccatc tttaaagcgt tgtggcgtcg gtatcaaact gatcattcta aaagttggcg
     2761 aattgatgag acttatattc gtgttaatgg tcgttcgggc tatttgtatc gcgctattga
     2821 cagtaacggt ttaaccttaa attttgagct gcgaaaacac cgtgataatg ataaatttcc
     2881 aagggcttcg ctcttgctcg tcaagctctt gaggcaacgg acttttaaat actgaacgcc
     2941 acttagggtc ttgatatcgt tttttgaact gttttttgaa ctgtttttta aaagttttag
     3001 tatatttaat tgctttcgtc atttattttg aggactccaa tgcatcatcg gagctaagca
     3061 attgatctaa ttctttaagg ctatgcgcct ctggtagctt ttctttgcca gataaatcat
     3121 caataacttc ttggatcgag tcctttaatt gccgattagg gattgaatag tatttaggca
     3181 agccctcgtt tgcaactgtt gtcagtgtca tgcgcataaa atcggaaatt gttagaccgt
     3241 gctcagccaa tacgtccttg gctttacttt taatggttcc atcaattcga gcttcaattc
     3301 ttgccattct catcacctca acagtattgt acgccagatg gcgtacaaac gcaattggac
     3361 taaactggtt aaatccttta caggacaagc aaatattctt aaattaaaga caataagaca
     3421 gttagaaagt ggggatttca tgattgattt gattgtttta gtattgttaa ttctattagc
     3481 tatctatgca cataaaaaac atgccgcagg tgaaaagttg atcactaagc cgcttcgttt
     3541 ctttattttt ccagtccact ggtggctgcg aaatgctatt tttaaattta ccggcagcaa
     3601 ctttatcacc ggtatcattt ggttctttgc tgggattttt atttttctgt tattcatacc
     3661 agtttatgta atcaataaaa ctgctggttt tatctttgct tattatcttg ctttcggcta
     3721 ttttttctgt ttatttccac aaaatactgc tttagccggt gacagtgatc ttggtcgggc
     3781 caagtatctt agctattctg agcttaaaca tggtggctta atcactaata ccggtttggt
     3841 tttaggcaaa aagcaacatc gcttagtcgc taaaccatct gattttgaag gcaatgttgc
     3901 tgtttttggt ggtgctggta ccggcaaaac cgctggcaat ttaattccca cccttttgac
     3961 tttccaaggt aatgctttgg tcgttgatat caagcccgaa ctgctaaaaa ggacgggcca
     4021 tctacacccg aataaagaag tcttaaattt cattaatccc aaacaatcct atgatccctt
     4081 agctaccttg cagacttaca ccgatgtcac cgacttggct aaaaccttga ttcccattag
     4141 ttcggatatc aaagaacctt attttcgtga gagtgctcaa aatattctgg caagtgcctg
     4201 ctgggaattt aaaggccaaa aatcgtttag tgaaattgct gaatttctca cggctacccc
     4261 ggctgatgcc attattaaac aattatctgc tagttcaaaa tctgaaactc gcattttaat
     4321 taatgcagtg gccggcatta aaactgaaca attagctagt gtgatgaatg aactgcgtaa
     4381 tacgctagtc atctttgcca ctgatccagt cttaaagcaa ctagccggcc acagcgctaa
     4441 ctcgatccaa ccacaagata ttgaaaccaa ttggatttac ctggttttgc cggaaagtaa
     4501 attaaaggtc taccagccct acttagcttt aatcgtggcc caatttaccc gttatttaac
     4561 tcaacgacct gaaaaatccc agcctaatct tttgttagcc ctcgacgaat ttcctcgttt
     4621 gggctatcta ccagcgtttg ctgatgcgat ttccacattg cgttctcgca acgtttcagt
     4681 catgatcctt ttgcagtcat tagcgcaatt agatcagttg tatcaggaaa ctggccgtaa
     4741 aatcatcatg gataacatgc actatgtcgt agttcataat gctttagatc ataccagtca
     4801 acaatacttt tctgatcggg ctggtactaa aactgccgtg gctaaaagcc attcttatgg
     4861 taccggtggt tccggaggca ccatcgatgc cctctttggt tcgtcgtcaa cttcttataa
     4921 tcaacaatct gcaccgctga ttcggccgga agaatttgcg accttaaaac agcccattct
     4981 ttacgcttat caattaggca tcacgccggt tgataaggct tattggtttg aagacaacca
     5041 catgaagtcc atggttgaat taaatgatta aaaataatat taaagaaatc attttaccac
     5101 aatataccga aatggtataa taactattga ggtgaagaaa agtatggaat acgttgctga
     5161 gaaccggaaa ctagctaaaa ttttaaacga tccccgtttg ctggttaaaa actttggccg
     5221 tgatcgggcc aaacgtattc aatcccggct tgatgagttt gatgctgctg ataccctgca
     5281 gcagattcca tctgatccac cacctcgctg tcaccgattg cataacaatt tagaaggtaa
     5341 atttgctgtt gatgtcagta aaaatttccg cattgttttc gagggttatg ataaatccga
     5401 tcaactttca gttgaaaaat cagcaattgt gaccgtccaa attttaaaga ttgaagacta
     5461 tcattaagga gttgaaaagt atgctgcatc gcgagaatag tattcgacag tatcacacca
     5521 gttcagctgc cgatctcatt aaagaaacca tggactttta tcaaattact caaactgatc
     5581 tagccgctcg cttaggggtt agtcagaaaa atatttcaga tattcttaaa cgcaaacgat
     5641 tcatcaatga gttattggct ttaagaatcg aaactgttat gggtatttct agtcaattac
     5701 tccttaactt agatgccaac tttaaattac atcaagccaa ggaaaatgct aagaattctg
     5761 agcccgacca tcaatcggat aagttcctta aacgatatga ttgggtatca gcctaggctt
     5821 gaataattgt aagtgtggta agtaagccgt cttggttatt gaattagtaa tttagcagtg
     5881 attgtttaaa aacaatcact gcttttttga tcaagctaaa ttagcttgcg ccgtttgcgc
     5941 aaaattccgc ctgaagggct cctgctgaag gcatgctcat gatgcaaaat cattcggcca
     6001 accgccctgt ctggccgact tttttactca aattccgata ggaaatctga gtaaaaaaac
     6061 gcggagcttt gccaaaaagt ggctagccaa ccggttaacc attttggcat tgcgcagcga
     6121 acttgggggt caagggggag cgttagcttt cccccttgca agcaccgctg ctgcaacaaa
     6181 cgtagtcttg tggctagcat gcgggttgct tgccaaacct ttgttattcg attatcattg
     6241 ggaggaattc agcctacggc tgaaccgact tttgatatct cgaataactt tgcccgcagg
     6301 gcaacggagg tgggatttgt gaacgaacca caaaaaaagg ctagcaccaa atcgacgact
     6361 aacgttcatc gccgggctag caaacaaatt aattttcggg tgagtgaacc ggactatcta
     6421 aagctggcgc aatcggcgaa aactttaaat atgtccgtgc cagcttttgt caaaaagaag
     6481 gcccaagggg cgcgcttagt ttcccccaag attgctgccc aagatgctca aaatatcacc
     6541 catcaattag ctaaaatcgg tagcaatctt aatcaattgg cccatcatgc caatcaaggt
     6601 ggtcaagtgg atccccaagc attaaggaat ttacaaaacg aggtgcagca cctatggcaa
     6661 caactcacat aaaacgctcg accagtgcgt ctcgattagt taattacgct gaaaaacgcg
     6721 ccgtcaaaaa agacggactt aatttagata ttcagtacgc gaaaagcgaa ttgaaacaag
     6781 ttcgggacgt ctatggcaat ccgggcaaaa cccaagcgta tgccagccgg attgctttta
     6841 gcccgttgga atttaatccc aaagatcccc atgaccaagc aaccgtctta gccgttgcta
     6901 aagagattta tgctcaagcc tatcctaatc aacaggtcgc cctttatgaa catgccgaca
     6961 ccgactcgtt acacgtccat gctgtcattg gcgcgattaa tctggaaacc gggcaaaaat
     7021 tgcatggcaa ttggcatcaa taccgcgatc acttagtcca catcactgat caggtgtgtt
     7081 gggaacatgg cttgatggtc accaagcctg atcccaaccg gcatgagaaa cggactatgg
     7141 ctgaaattaa gctgcgcgct aagcaacagc ccacttggaa agatcaaatc cgccaagccg
     7201 tagatcacac tatgcagaat cccctcattc gcgattttca ggcctttcaa tccgatttaa
     7261 agcaacaggc agtaaaagta tggcagcggg gcaagaacct cacctatcaa cttttaggca
     7321 ccaattacaa gtcacgaggg accaaacttg ggcttgatta tgaaaaggag acgattttta
     7381 atgagttggc aagaagacaa ttccaatcaa aaaacaacca gcaaccccaa cgagccgtta
     7441 acgcaacaaa tgaaccagct caatcaaacc ctgaccgaac tccgcaatta ccagggcacc
     7501 cagattcaac tgcaagccac ggccaaaacg tcgttggatc aacaactcca gcagatcgaa
     7561 cagactgctc aacaggtcaa tcaccagttt cagacgacct taaacaactt agacgccagc
     7621 aacaacagct cacaggccca attaaaacag accttacaaa acgcctacgc agcctttcaa
     7681 aagcagacca acctaatcag tcagcaaaat ctgaccgcac tcaaacggat ccaaaccgag
     7741 caagaccaaa acaatcagca cctcagccaa ctagacgacc aagtgaacca gaccattcaa
     7801 gaaacgatgg cccgagtcgc taaacaggtg gatcagcaat ttcaaaccac ccaaaaacgg
     7861 ttctcttggt ttgaaattaa aaattatttg ctggcggtga ttccaactgg tttgttgacg
     7921 ggactagttt tttggctcct aaccaaattt ctcagttagg taaaacggat atacaagtgg
     7981 ctttgtttca caaactgcgt cacatatttt cttaagttta atcatggtta ttttgcttct
     8041 cttgattaat aaacatgatt ttaaagctgc cttagcttat ttagcttatt attggttcaa
     8101 aattcatttg acagccaatt taaatcaatc ttggtataaa tatgtgtcaa gcagctaaaa
     8161 tctcttagaa acgattttac agccttttag gattagtagt acaaccaact gttgtcggct
     8221 ggtttttctt ctccggggtg ctcatcataa tatcttctag ccgccttctt attccagtag
     8281 ttggcaaaga ggttttgcat ggtgccgtat aaataattct ccacgtcttt aatctgcttc
     8341 tcgttacttc ttaaggcatt aaagtaacgt cttaaggtct tagtcattaa aggctgtaac
     8401 tcgggatcat ctagtggaat taagacccct atgtcctggt ggtctttttc aacgcggtat
     8461 ttagcattta agataatgcc gataaagcgc cgcatttgtt gtggggttcg gcaccaaaaa
     8521 ctaagcagtt ggacggcttt gggttctaag aagacgggta gcccaccgtc tttgtcagtt
     8581 aagaactcat tggcatgttt aaccagatct tggttttgtt gttcaatttc tgatgatgag
     8641 aaattagttg tggaaaagtc caacttttga gtatctatat tgtatctatt agtatctatg
     8701 tttttaaagt ctttatatag attgtgtccg attttcggat tttcgcttgt agcaagggtt
     8761 tgtggggtgt cgtcaacgaa ctttcgcgaa cgtccgattt tcggattttc gcttgtagca
     8821 agggtttcaa cggtctcctg cgaacgtccg attttcggat tttcgcttgt agcaagggtt
     8881 tgcggctctt tttgagcata ttcaccgcgt aaatagacat cggttggctg catatctagt
     8941 tcggctaggt aaagtcgatt gggttcgttt ttccctgttt tgggattaaa atgcatagct
     9001 ttttgataaa gtagcccagc attttctagt tctttcttga cgttggctaa tttatcattt
     9061 gagcagttga acaaatcttt aagttcttga ttggtaaaaa taaaatagat gtgcccctct
     9121 tcatcaaccc agtggttgcg taaggaatac tctaaccggt cttttagcac catataagct
     9181 aacttagcag tatcgcttaa ctttcgatat tgttggccat acattaatac tttgggaaac
     9241 tgaaagaaca aggccctata aacgttgtca gcttgataaa acttaaaatt tgcttgatcc
     9301 attataaaaa ctccctttct atatccaacc catgctggct caaaagagag ttgctaaaac
     9361 atctgacttg ctttaaaata caaatctgat atgctctagc tgaattacaa agctttcatt
     9421 ggtctggcgg ctttataatt catcagcatg gattctcttt cttggttgcc cattcggcaa
     9481 cttttttatt ttattcaaca atcaaaataa aaatggacta ggcagccttg ctagctactt
     9541 agtccattga atttaatttg tttttaacta tccttcactt gtcccctggg actggtttgc
     9601 ggtataatta acctacaaat taagaacaat tttcagtcga ttttaacttg gcggtgaaaa
     9661 tcgactgaat ctaagtagct gtctggtagc tactttctaa taagcggaaa agatcttgat
     9721 ccctggtggg ttgggatctt tttcgtttat tagcctgttt tttatccagt tgttaaatta
     9781 atcttagttt agcatagcgc ttaccagccg gcaaacccta attgtggggt aatttcactg
     9841 attggttagt ttgattaaat gatttttgaa caaaaaacga caagaacgac aagcagattt
     9901 tgtttttagt tgtcgattgg cgatcttgtc gtttttaact tataatttaa gacggattat
     9961 tgaggtggtg aaactattgg ggaagacaat tcgacaactt tcggaagaat tgcagttatc
    10021 aaaacaagct attaatcagc gtatatctag tattaaagac tttcgaagca agcacaccca
    10081 taaagttaaa aatcatctgg aaatagacga gcagggtgtt aaaatgcttg ctaatttcga
    10141 caagcaaaag cgacaagatc agcaagtaaa tcgacaagaa cgacaagccg aaaacgacaa
    10201 gcaagataaa aagcaaacta acattaatga tgttttgctg aagcaacttg atgttaaaga
    10261 tcagcaaatt tccaaattac aaaagtcctt ggatcagcag caacagctac agttagcgac
    10321 acttgcggaa aatcggcaat taaaaggtca tatccaaaaa ttgaatggtc ttcttgaatc
    10381 ttctaattca actcaaaaac gacaagccac caagaaaaat gacaacttgc cgaatagtgt
    10441 taaaccccat aatatcaagg ataaaaacga caagcaagat agaaatagtg ttgttggtgc
    10501 tggcaaaatg caaagaaaaa tacataaaaa taaaaccaat aagagttggt ggcatttttg
    10561 gtaatactaa gccaaattct aaatttattt tcgaaattaa ttattaatag aaggtttgaa
    10621 ttatttgtcg taacgagttg gcatataaaa attccttcct tttgagagac gatttattca
    10681 ttatacgctc tcttaaaagt tgtctcagga atcagcttac atccagttca ctttattgac
    10741 ggtaagggaa tcaccggcat tttaaacgct attggcatgt acgaaatttt tcttcaagtc
    10801 accaataaaa ctggtgaaaa aatagcaatt acagtcttta agaacgccat taaataaatt
    10861 aactgaaaaa atatgaaata gagggcaata aaatgtattc acgtataaag atagctagcg
    10921 tatcttgtct atgtatcttc tccgctttga tgttaaccat agcatcaaac accttaaaca
    10981 aatacaattt actgctcttt ttaggaagtg gcatatccct gctagccaca attatactgt
    11041 ttggaatcct ttttcgaatt aaaaaatatt aaataggttc cataacaaaa gagatgactt
    11101 caaacgcagt tgtgcaagta acatttgcgt gactaatgct agtaattctt gctaggattg
    11161 ccttagatcc ttgattatga tttaggagga gtgagatttg agctttaaag aagatatcaa
    11221 gaccttgcgc aggcaatcta atttaaccca agaagcgtta gcccaacaat tgcatgtaac
    11281 ccgccaaaca gtctcaactt gggaaactgg caagaacatg ccaaatttag agaccctgca
    11341 tgctttgagt caattgttta acatctcact cgaaaaactt ctatttaacg aggagattac
    11401 aatgaaaaaa gataaagacc cctctttggc cacccagata gatcatgatg ttaagcttaa
    11461 aagtcgttat cgtcgttgga cttttggttt aggtggcttg attgcactag cactggttag
    11521 tattggtatt ttatgtttgg gatactataa aggtattggg acgattgatc gatttgatcc
    11581 gtttttatcc tataaagtcg ggtacactaa attacctagt gaaaaggaaa tttcgcctaa
    11641 caataaggca accaatggtt actggaccgc ttggttcact gacaatacga tggggaatga
    11701 atggaccaaa ctaaccttaa cgacggggct taatcctggg gtcaaaaatc cttatgtgat
    11761 ggcttatcat aagggcagtt atgttaaagt tgcgcgtatc gttcctcgca cctacattaa
    11821 tcagacttat gttagcaacc tggcagcgct agatgccttg ttaaatcata agggaaatac
    11881 agcaactaac aatcatgacc ttaagaagta taagacacaa atccacatat cagacactgt
    11941 ccaacagtta gtaactgaat agagaaccac caagtcacaa tccggtaagt ggctttaggg
    12001 tcaacttcaa ataacgccta taaaaagggc aagcagagaa tcattgcttg ctcttttcgt
    12061 gttttatagg cacaattatt ttgaaatcag gaggatattt atgaaatttg gtgatcgtct
    12121 aaaaaaggga agaacagaat tgaatcttac tcaggaacaa gttgctagag atttctttat
    12181 tactagacaa accatttcta gctgggaaaa tgaaaaaact tatcctgaca ttatcagctt
    12241 aattaaatta agtgactact accatgtttc actagatact ttgttaaagg aggatacagg
    12301 tatgcgtgag tttttggaaa agaaagacgt tacaagaaaa ataaaaccaa tttatcgcaa
    12361 tcttatagtt attgatttac tagtctgttc attactactt ggagattttt ttaatctaat
    12421 acatttaggt gtatttatac tgccaatatt tcttttgtta ttgtgcagtg tatctgcact
    12481 aaacaagcta aacgctttca acaattctag ttctcttgga ttaaaataca cttggcaaaa
    12541 atatctatct ggagaaaaag ggcttaaata ttctcttgtt atgccaacat tatttataat
    12601 ttcaggagtt gcttttcttt tattaaaaga actgtatatt ggtggaatca tcataatagc
    12661 aggagcttta cttatatttt ttatttttac gcaaaaaaaa gattaataat gtcactcata
    12721 tattataggg tccataatta acaaatcgcc cctcaaaaac attgaaagaa taacccccaa
    12781 tatctataat gtggatattg ggggttattt atcataatat ttgatttata acgcatatta
    12841 agtcactagt ttttccggga attagattta ccgctcattt caagattacc actttcataa
    12901 tgggcccaac atgaatagat ttcgactatt ttagttactt tatcaatggt ataaacgaca
    12961 cgatgctgtc catttattct tcgagaatag taaccagccg caggtggtgt taatttttca
    13021 aatgactgta ttggtttata tggatcagat tccaatacat tttttatttc ttcaaatgac
    13081 tgacgtaatg ggcttcttaa aacttttttt aaatcacctt tagctgatga ttttattttt
    13141 actttccaac gattactcat gatcaatttc tttgatcatt tcgtctaaat caaccgattc
    13201 atcatcttta cggctcaagg tagcttgaat ttgaccattc atcattaagt tcatggtttc
    13261 ctgtaatgcg tcatagtctt tttttccaat caaaacggca ctacggctgt cattggatcc
    13321 tgcaataata acaggttggg agtcccgatt agcgtttttg atcagtgaaa atagattggt
    13381 tcgtgctgta gttggattaa taattttctc cat
//
