LOCUS NC_008498 13413 bp DNA circular BCT 31-OCT-2006 DEFINITION Lactobacillus brevis ATCC 367 plasmid 1, complete sequence. ACCESSION NC_008498 VERSION NC_008498.1 GI:116334867 KEYWORDS . SOURCE Lactobacillus brevis ATCC 367 ORGANISM Lactobacillus brevis ATCC 367 Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. REFERENCE 1 (bases 1 to 13413) AUTHORS Makarova,K., Slesarev,A., Wolf,Y., Sorokin,A., Mirkin,B., Koonin,E., Pavolv,A., Pavlova,N., Karamychev,V., Polouchine,N., Shakhova,V., Grigoriev,I., Lou,Y., Rohksar,D., Lucas,S., Huang,K., Goldstein,D.M., Hawkins,T., Plengvidhya,V., Welker,D., Hughes,J., Goh,Y., Benson,A., Baldwin,K., Lee,J.-H., Diaz-Muniz,I., Dosti,B., Smeianov,V., Wechter,W., Barabote,R., Lorca,G., Altermann,E., Barrangou,R., Ganesan,B., Xie,Y., Rawsthorne,H., Tamir,D., Parker,C., Breidt,F., Broadbent,J., Hutkins,R., O'Sulllivan,D., Steele,J., Unlu,G., Saier,M., Klaenhammer,T., Richardson,P., Kozyavkin,S., Weimer,B. and Mills,D. TITLE Comparative genomics of the lactic acid bacteria JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (42), 15611-15616 (2006) PUBMED 17030793 REFERENCE 2 (bases 1 to 13413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (21-OCT-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 13413) AUTHORS Lucas,S., Copeland,A., Detter,J.C., Glavina del Rio,T., Pitluck,S., Grigoriev,I., Rokhsar,D., Slesarev,A., Pavlov,A., Pavlova,N., Karamychev,V., Polouchine,N., Shakhova,V., Kozyavkin,S., Makarova,K., Koonin,E., Mills,D.A. and Richardson,P. CONSRTM US DOE Joint Genome Institute (JGI), The Lactic Acid Bacteria Genome Consortium and Fidelity Systems Inc. TITLE Direct Submission JOURNAL Submitted (22-MAY-2006) US DOE Joint Genome Institute, 2800 Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CP000417. URL -- http://www.jgi.doe.gov JGI Project ID: 2662178 Source DNA and bacteria available from Milton Saier (msaier@ucsd.edu) Bacteria also available from ATCC: ATCC 367 Contacts: Milton Saier (msaier@ucsd.edu) Paul Richardson (microbes@cuba.jgi-psf.org) Annotation done by Kira Makarova and Eugene Koonin Finishing done by Fidelity Systems Inc. (Gaithersburg)URL -- http://www.fidelitysystems.com Project Information available at: http://genome.jgi-psf.org/mic_home.html The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. (http://www.genome.gov/page.cfm?pageID=10506376). COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..13413 /organism="Lactobacillus brevis ATCC 367" /mol_type="genomic DNA" /strain="ATCC 367" /db_xref="ATCC:367" /db_xref="taxon:387344" /plasmid="1" gene complement(352..1281) /locus_tag="LVIS_A01" /db_xref="GeneID:4414791" CDS complement(352..1281) /locus_tag="LVIS_A01" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_796394.1" /db_xref="GI:116334868" /db_xref="GeneID:4414791" /translation="MKEKNSNYNRFMAETQVTWEHYERVRKCFGNVGSFAYWPERDSS STQIPGKGKRAIKYKALPIIAHNESEYIAKKLNKHLHNGVVLLGLNFGVPKDCLGFTE FEKIEALRSMNDMSNQYGGKYGRKSLNVYLNEDYYSNVENVVGDPIGYDEVVCRYTEG AYMTDFFKYSIETKLDNKKSACSKPTGMPSTDGEKLLKQYRKEEFEHLIEVNAKGLKK ELDALGTPDNVIIAPMSARLRDKDVEDAICKCLERNVKFINCLEHYQSRSGNKPEKDK CIKHPLQARFARNLIKANEGIEKIVQERLSEQN" gene complement(1613..2449) /locus_tag="LVIS_A02" /note="LactoCOG number LaCOG03195" /db_xref="GeneID:4414792" CDS complement(1613..2449) /locus_tag="LVIS_A02" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_796395.1" /db_xref="GI:116334869" /db_xref="GeneID:4414792" /translation="MSKYKRNFQEVNEQWNDQINFIQESIRAFDNGNEKEARRLATAI RVMFHDSRESLSIYNQLIKWSGKDMIFKSITDIYSPANLISSWLQLALQQSKNGLRYI PNLDESVNRRIFFMNFDDWWNQIIFDDKKNCFTRRDVVLFVANKDGGAHLDSEIKESY ANIVKYNSIGWTDSDGKSPSNNPLYTSIRVISQEILDSIKLNLYSPHRVTYINKGHEM EMRFVKQGEKKRYPWSSTEVQKSPETQSIVDKHQKKSRTLYIREYQGENEGKIRVEYI GK" gene complement(3023..3307) /locus_tag="LVIS_A03" /note="LactoCOG number LaCOG03281" /db_xref="GeneID:4414793" CDS complement(3023..3307) /locus_tag="LVIS_A03" /codon_start=1 /transl_table=11 /product="DNA-damage-inducible protein J" /protein_id="YP_796396.1" /db_xref="GI:116334870" /db_xref="GeneID:4414793" /translation="MARIEARIDGTIKSKAKDVLAEHGLTISDFMRMTLTTVANEGLP KYYSIPNRQLKDSIQEVIDDLSGKEKLPEAHSLKELDQLLSSDDALESSK" gene 3440..5071 /locus_tag="LVIS_A04" /note="LactoCOG number LaCOG03161" /db_xref="GeneID:4414794" CDS 3440..5071 /locus_tag="LVIS_A04" /codon_start=1 /transl_table=11 /product="Type IV secretory pathway, VirD4 component" /protein_id="YP_796397.1" /db_xref="GI:116334871" /db_xref="GeneID:4414794" /translation="MIDLIVLVLLILLAIYAHKKHAAGEKLITKPLRFFIFPVHWWLR NAIFKFTGSNFITGIIWFFAGIFIFLLFIPVYVINKTAGFIFAYYLAFGYFFCLFPQN TALAGDSDLGRAKYLSYSELKHGGLITNTGLVLGKKQHRLVAKPSDFEGNVAVFGGAG TGKTAGNLIPTLLTFQGNALVVDIKPELLKRTGHLHPNKEVLNFINPKQSYDPLATLQ TYTDVTDLAKTLIPISSDIKEPYFRESAQNILASACWEFKGQKSFSEIAEFLTATPAD AIIKQLSASSKSETRILINAVAGIKTEQLASVMNELRNTLVIFATDPVLKQLAGHSAN SIQPQDIETNWIYLVLPESKLKVYQPYLALIVAQFTRYLTQRPEKSQPNLLLALDEFP RLGYLPAFADAISTLRSRNVSVMILLQSLAQLDQLYQETGRKIIMDNMHYVVVHNALD HTSQQYFSDRAGTKTAVAKSHSYGTGGSGGTIDALFGSSSTSYNQQSAPLIRPEEFAT LKQPILYAYQLGITPVDKAYWFEDNHMKSMVELND" gene 5144..5467 /locus_tag="LVIS_A05" /db_xref="GeneID:4414795" CDS 5144..5467 /locus_tag="LVIS_A05" /codon_start=1 /transl_table=11 /product="Plasmid maintenance system killer protein" /protein_id="YP_796398.1" /db_xref="GI:116334872" /db_xref="GeneID:4414795" /translation="MEYVAENRKLAKILNDPRLLVKNFGRDRAKRIQSRLDEFDAADT LQQIPSDPPPRCHRLHNNLEGKFAVDVSKNFRIVFEGYDKSDQLSVEKSAIVTVQILK IEDYH" gene 5481..5816 /locus_tag="LVIS_A06" /note="LactoCOG number LaCOG01493" /db_xref="GeneID:4414796" CDS 5481..5816 /locus_tag="LVIS_A06" /codon_start=1 /transl_table=11 /product="Transcriptional regulator, xre family" /protein_id="YP_796399.1" /db_xref="GI:116334873" /db_xref="GeneID:4414796" /translation="MLHRENSIRQYHTSSAADLIKETMDFYQITQTDLAARLGVSQKN ISDILKRKRFINELLALRIETVMGISSQLLLNLDANFKLHQAKENAKNSEPDHQSDKF LKRYDWVSA" gene 6654..7823 /locus_tag="LVIS_A07" /db_xref="GeneID:4414797" CDS 6654..7823 /locus_tag="LVIS_A07" /codon_start=1 /transl_table=11 /product="Relaxase/Mobilisation nuclease domain" /protein_id="YP_796400.1" /db_xref="GI:116334874" /db_xref="GeneID:4414797" /translation="MATTHIKRSTSASRLVNYAEKRAVKKDGLNLDIQYAKSELKQVR DVYGNPGKTQAYASRIAFSPLEFNPKDPHDQATVLAVAKEIYAQAYPNQQVALYEHAD TDSLHVHAVIGAINLETGQKLHGNWHQYRDHLVHITDQVCWEHGLMVTKPDPNRHEKR TMAEIKLRAKQQPTWKDQIRQAVDHTMQNPLIRDFQAFQSDLKQQAVKVWQRGKNLTY QLLGTNYKSRGTKLGLDYEKETIFNELARRQFQSKNNQQPQRAVNATNEPAQSNPDRT PQLPGHPDSTASHGQNVVGSTTPADRTDCSTGQSPVSDDLKQLRRQQQQLTGPIKTDL TKRLRSLSKADQPNQSAKSDRTQTDPNRARPKQSAPQPTRRPSEPDHSRNDGPSR" gene 7381..7959 /locus_tag="LVIS_A08" /pseudo /db_xref="GeneID:4414798" gene complement(8193..9302) /locus_tag="LVIS_A09" /note="LactoCOG number LaCOG03083" /db_xref="GeneID:4414799" CDS complement(8193..9302) /locus_tag="LVIS_A09" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_796401.1" /db_xref="GI:116334875" /db_xref="GeneID:4414799" /translation="MDQANFKFYQADNVYRALFFQFPKVLMYGQQYRKLSDTAKLAYM VLKDRLEYSLRNHWVDEEGHIYFIFTNQELKDLFNCSNDKLANVKKELENAGLLYQKA MHFNPKTGKNEPNRLYLAELDMQPTDVYLRGEYAQKEPQTLATSENPKIGRSQETVET LATSENPKIGRSRKFVDDTPQTLATSENPKIGHNLYKDFKNIDTNRYNIDTQKLDFST TNFSSSEIEQQNQDLVKHANEFLTDKDGGLPVFLEPKAVQLLSFWCRTPQQMRRFIGI ILNAKYRVEKDHQDIGVLIPLDDPELQPLMTKTLRRYFNALRSNEKQIKDVENYLYGT MQNLFANYWNKKAARRYYDEHPGEEKPADNSWLYY" gene 9977..10564 /locus_tag="LVIS_A10" /db_xref="GeneID:4414800" CDS 9977..10564 /locus_tag="LVIS_A10" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_796402.1" /db_xref="GI:116334876" /db_xref="GeneID:4414800" /translation="MGKTIRQLSEELQLSKQAINQRISSIKDFRSKHTHKVKNHLEID EQGVKMLANFDKQKRQDQQVNRQERQAENDKQDKKQTNINDVLLKQLDVKDQQISKLQ KSLDQQQQLQLATLAENRQLKGHIQKLNGLLESSNSTQKRQATKKNDNLPNSVKPHNI KDKNDKQDRNSVVGAGKMQRKIHKNKTNKSWWHFW" gene 11198..11962 /locus_tag="LVIS_A11" /note="LactoCOG number LaCOG00006" /db_xref="GeneID:4414801" CDS 11198..11962 /locus_tag="LVIS_A11" /codon_start=1 /transl_table=11 /product="Transcriptional regulator, xre family" /protein_id="YP_796403.1" /db_xref="GI:116334877" /db_xref="GeneID:4414801" /translation="MSFKEDIKTLRRQSNLTQEALAQQLHVTRQTVSTWETGKNMPNL ETLHALSQLFNISLEKLLFNEEITMKKDKDPSLATQIDHDVKLKSRYRRWTFGLGGLI ALALVSIGILCLGYYKGIGTIDRFDPFLSYKVGYTKLPSEKEISPNNKATNGYWTAWF TDNTMGNEWTKLTLTTGLNPGVKNPYVMAYHKGSYVKVARIVPRTYINQTYVSNLAAL DALLNHKGNTATNNHDLKKYKTQIHISDTVQQLVTE" gene 12101..12706 /locus_tag="LVIS_A12" /note="LactoCOG number LaCOG00006" /db_xref="GeneID:4414802" CDS 12101..12706 /locus_tag="LVIS_A12" /codon_start=1 /transl_table=11 /product="Transcriptional regulator, xre family" /protein_id="YP_796404.1" /db_xref="GI:116334878" /db_xref="GeneID:4414802" /translation="MKFGDRLKKGRTELNLTQEQVARDFFITRQTISSWENEKTYPDI ISLIKLSDYYHVSLDTLLKEDTGMREFLEKKDVTRKIKPIYRNLIVIDLLVCSLLLGD FFNLIHLGVFILPIFLLLLCSVSALNKLNAFNNSSSLGLKYTWQKYLSGEKGLKYSLV MPTLFIISGVAFLLLKELYIGGIIIIAGALLIFFIFTQKKD" ORIGIN 1 atgattcccc tcctcaactt atctaatatt ataggcgtac atgatagcgt acgtcaatta 61 caaactatta tatcgtcaaa ggagattatg acttatgcaa caaatcgtcc tacccatcaa 121 agactctaac gttctcaaag aggtccaaga caccttactt cataatttta aagctggttg 181 tcgcaactat acgatttttc aagttggcaa ggccacctta ttacgaatga gcgatgttat 241 gcggctccgt tggactgatg tctttaacga aaacggaacc gtgcgttaga atacgtttat 301 ccacacccta tcgcatacga aatgacagtt gtacaatgtt ttacaaggat tttagttctg 361 ctcagaaagg cgctcttgca ctattttctc aatcccttcg tttgccttga ttaagtttct 421 agcaaatctc gcctgcagtg gatgcttgat acacttgtct ttctcaggtt tattgccgga 481 acgggactga taatgttcta agcaattaat aaattttacg tttctttcga ggcacttgca 541 tattgcgtcc tcgacatcct tatctcttaa tctggcactc atgggtgcaa tgataacatt 601 atcaggcgtg cctaaggcat caagttcttt ctttaagcct ttggcattca cctctatcaa 661 gtgttcaaat tcctctttac ggtactgttt cagtaacttt tcaccatcag tcgaaggcat 721 tccagtgggc tttgaacagg cacttttttt gttgtcaagt ttggtctcga tactatactt 781 aaagaagtct gtcatgtaag cgccctctgt ataacgacaa actacttcat catagcctat 841 tggatcacca acaacattct caacgttgct ataatagtct tcgtttaaat acacattcaa 901 tgattttcgc ccatatttac caccatattg gttagacata tcattcatgc ttctaagtgc 961 ttcaatcttt tcaaactctg tgaatccaag gcagtctttt ggcactccaa aattcaaccc 1021 aagcaacaca accccattat gtaaatgttt atttagtttt ttagctatat attcagactc 1081 attatgcgca ataatcggca aggctttata cttaatagca cgcttacctt ttcctggaat 1141 ttgtgtactg ctggaatctc tttcgggcca ataggcaaag cttccaacgt tgccgaagca 1201 tttccgtact cgttcataat gttcccacgt tacttgggtc tcagccatga acctattgta 1261 gttgctgttc ttctccttca ttatatttct ccttatcctt tgtagcttta ttaaaacatt 1321 gcttatgttt gtatggataa cgcggttaat taaatcatta atcccttcgt attgcttatt 1381 atgcgcttaa gtcaataatg ttttgtcgtt ctaatgtaat gttcctacta ttgatacatt 1441 ctatatacgt gaaaccgatt tgactattag aaatatagag attgcaactt agaacgagat 1501 tttgatagta cgagcgtgcc taatacagga atactttgta tcgatcagca ttcaaagtcc 1561 gtccaaaaaa tcacaccttc gcggatcaca caaacaaaag tttctattac tcttattttc 1621 caatatattc aactctaatt ttgccttcat tttcaccttg atattctcta atataaagtg 1681 tccgtgattt tttttgatgt ttatcaacaa tgctttgagt ttcaggtgat ttttggactt 1741 cagtgctaga ccacggatat ctttttttct ctccctgctt cacaaacctc atttccattt 1801 cgtgtccctt atttatatag gtcactcggt ggggactata aagattcagc ttgatcgagt 1861 cgagtatttc ttgagaaatc actctaatgg atgtataaag tggattatta gaaggggatt 1921 taccgtcact gtccgtccaa ccaatagaat tatatttaac tatattcgcg taggattctt 1981 taatttctga atcaagatgg gctcccccat ccttattagc cacaaaaagg actacatctc 2041 ttctcgtaaa acaatttttc ttatcatcaa aaattatttg gttccaccaa tcatcaaaat 2101 tcataaaaaa gatccttcta tttacacttt catccaagtt tggaatgtac cttaacccat 2161 tcttactttg ttgtaatgct aattgcaacc atgaagaaat caagtttgct ggtgaataaa 2221 tatctgtgat agatttaaaa atcatgtctt tccctgacca cttaataagc tgattataaa 2281 tagacaaaga ctctctcgaa tcatgaaaca tcacacgaat cgcagttgca agtcttctag 2341 cttctttctc attgccgtta tcaaatgcac gaatcgattc ctgtataaaa ttaatctggt 2401 cattccattg ctcattaact tcttgaaagt ttcttttata ttttgacatg ctcaaaccgc 2461 cctttcacta gtcctagtgc atactttctt ctctgacttc attttagtat atttggggca 2521 aaaatggggg attaagcgca tgaatcactt caaaggacgt cactttcaaa gagacatcat 2581 cttagccgcc gttggatacc attttagatt cagtctcagc tatcgtgata tcgtcgaatt 2641 gcttcgggat caaagcatga ccgttcatca caccacggtc atgcgatggg tccatcacta 2701 tggccccatc tttaaagcgt tgtggcgtcg gtatcaaact gatcattcta aaagttggcg 2761 aattgatgag acttatattc gtgttaatgg tcgttcgggc tatttgtatc gcgctattga 2821 cagtaacggt ttaaccttaa attttgagct gcgaaaacac cgtgataatg ataaatttcc 2881 aagggcttcg ctcttgctcg tcaagctctt gaggcaacgg acttttaaat actgaacgcc 2941 acttagggtc ttgatatcgt tttttgaact gttttttgaa ctgtttttta aaagttttag 3001 tatatttaat tgctttcgtc atttattttg aggactccaa tgcatcatcg gagctaagca 3061 attgatctaa ttctttaagg ctatgcgcct ctggtagctt ttctttgcca gataaatcat 3121 caataacttc ttggatcgag tcctttaatt gccgattagg gattgaatag tatttaggca 3181 agccctcgtt tgcaactgtt gtcagtgtca tgcgcataaa atcggaaatt gttagaccgt 3241 gctcagccaa tacgtccttg gctttacttt taatggttcc atcaattcga gcttcaattc 3301 ttgccattct catcacctca acagtattgt acgccagatg gcgtacaaac gcaattggac 3361 taaactggtt aaatccttta caggacaagc aaatattctt aaattaaaga caataagaca 3421 gttagaaagt ggggatttca tgattgattt gattgtttta gtattgttaa ttctattagc 3481 tatctatgca cataaaaaac atgccgcagg tgaaaagttg atcactaagc cgcttcgttt 3541 ctttattttt ccagtccact ggtggctgcg aaatgctatt tttaaattta ccggcagcaa 3601 ctttatcacc ggtatcattt ggttctttgc tgggattttt atttttctgt tattcatacc 3661 agtttatgta atcaataaaa ctgctggttt tatctttgct tattatcttg ctttcggcta 3721 ttttttctgt ttatttccac aaaatactgc tttagccggt gacagtgatc ttggtcgggc 3781 caagtatctt agctattctg agcttaaaca tggtggctta atcactaata ccggtttggt 3841 tttaggcaaa aagcaacatc gcttagtcgc taaaccatct gattttgaag gcaatgttgc 3901 tgtttttggt ggtgctggta ccggcaaaac cgctggcaat ttaattccca cccttttgac 3961 tttccaaggt aatgctttgg tcgttgatat caagcccgaa ctgctaaaaa ggacgggcca 4021 tctacacccg aataaagaag tcttaaattt cattaatccc aaacaatcct atgatccctt 4081 agctaccttg cagacttaca ccgatgtcac cgacttggct aaaaccttga ttcccattag 4141 ttcggatatc aaagaacctt attttcgtga gagtgctcaa aatattctgg caagtgcctg 4201 ctgggaattt aaaggccaaa aatcgtttag tgaaattgct gaatttctca cggctacccc 4261 ggctgatgcc attattaaac aattatctgc tagttcaaaa tctgaaactc gcattttaat 4321 taatgcagtg gccggcatta aaactgaaca attagctagt gtgatgaatg aactgcgtaa 4381 tacgctagtc atctttgcca ctgatccagt cttaaagcaa ctagccggcc acagcgctaa 4441 ctcgatccaa ccacaagata ttgaaaccaa ttggatttac ctggttttgc cggaaagtaa 4501 attaaaggtc taccagccct acttagcttt aatcgtggcc caatttaccc gttatttaac 4561 tcaacgacct gaaaaatccc agcctaatct tttgttagcc ctcgacgaat ttcctcgttt 4621 gggctatcta ccagcgtttg ctgatgcgat ttccacattg cgttctcgca acgtttcagt 4681 catgatcctt ttgcagtcat tagcgcaatt agatcagttg tatcaggaaa ctggccgtaa 4741 aatcatcatg gataacatgc actatgtcgt agttcataat gctttagatc ataccagtca 4801 acaatacttt tctgatcggg ctggtactaa aactgccgtg gctaaaagcc attcttatgg 4861 taccggtggt tccggaggca ccatcgatgc cctctttggt tcgtcgtcaa cttcttataa 4921 tcaacaatct gcaccgctga ttcggccgga agaatttgcg accttaaaac agcccattct 4981 ttacgcttat caattaggca tcacgccggt tgataaggct tattggtttg aagacaacca 5041 catgaagtcc atggttgaat taaatgatta aaaataatat taaagaaatc attttaccac 5101 aatataccga aatggtataa taactattga ggtgaagaaa agtatggaat acgttgctga 5161 gaaccggaaa ctagctaaaa ttttaaacga tccccgtttg ctggttaaaa actttggccg 5221 tgatcgggcc aaacgtattc aatcccggct tgatgagttt gatgctgctg ataccctgca 5281 gcagattcca tctgatccac cacctcgctg tcaccgattg cataacaatt tagaaggtaa 5341 atttgctgtt gatgtcagta aaaatttccg cattgttttc gagggttatg ataaatccga 5401 tcaactttca gttgaaaaat cagcaattgt gaccgtccaa attttaaaga ttgaagacta 5461 tcattaagga gttgaaaagt atgctgcatc gcgagaatag tattcgacag tatcacacca 5521 gttcagctgc cgatctcatt aaagaaacca tggactttta tcaaattact caaactgatc 5581 tagccgctcg cttaggggtt agtcagaaaa atatttcaga tattcttaaa cgcaaacgat 5641 tcatcaatga gttattggct ttaagaatcg aaactgttat gggtatttct agtcaattac 5701 tccttaactt agatgccaac tttaaattac atcaagccaa ggaaaatgct aagaattctg 5761 agcccgacca tcaatcggat aagttcctta aacgatatga ttgggtatca gcctaggctt 5821 gaataattgt aagtgtggta agtaagccgt cttggttatt gaattagtaa tttagcagtg 5881 attgtttaaa aacaatcact gcttttttga tcaagctaaa ttagcttgcg ccgtttgcgc 5941 aaaattccgc ctgaagggct cctgctgaag gcatgctcat gatgcaaaat cattcggcca 6001 accgccctgt ctggccgact tttttactca aattccgata ggaaatctga gtaaaaaaac 6061 gcggagcttt gccaaaaagt ggctagccaa ccggttaacc attttggcat tgcgcagcga 6121 acttgggggt caagggggag cgttagcttt cccccttgca agcaccgctg ctgcaacaaa 6181 cgtagtcttg tggctagcat gcgggttgct tgccaaacct ttgttattcg attatcattg 6241 ggaggaattc agcctacggc tgaaccgact tttgatatct cgaataactt tgcccgcagg 6301 gcaacggagg tgggatttgt gaacgaacca caaaaaaagg ctagcaccaa atcgacgact 6361 aacgttcatc gccgggctag caaacaaatt aattttcggg tgagtgaacc ggactatcta 6421 aagctggcgc aatcggcgaa aactttaaat atgtccgtgc cagcttttgt caaaaagaag 6481 gcccaagggg cgcgcttagt ttcccccaag attgctgccc aagatgctca aaatatcacc 6541 catcaattag ctaaaatcgg tagcaatctt aatcaattgg cccatcatgc caatcaaggt 6601 ggtcaagtgg atccccaagc attaaggaat ttacaaaacg aggtgcagca cctatggcaa 6661 caactcacat aaaacgctcg accagtgcgt ctcgattagt taattacgct gaaaaacgcg 6721 ccgtcaaaaa agacggactt aatttagata ttcagtacgc gaaaagcgaa ttgaaacaag 6781 ttcgggacgt ctatggcaat ccgggcaaaa cccaagcgta tgccagccgg attgctttta 6841 gcccgttgga atttaatccc aaagatcccc atgaccaagc aaccgtctta gccgttgcta 6901 aagagattta tgctcaagcc tatcctaatc aacaggtcgc cctttatgaa catgccgaca 6961 ccgactcgtt acacgtccat gctgtcattg gcgcgattaa tctggaaacc gggcaaaaat 7021 tgcatggcaa ttggcatcaa taccgcgatc acttagtcca catcactgat caggtgtgtt 7081 gggaacatgg cttgatggtc accaagcctg atcccaaccg gcatgagaaa cggactatgg 7141 ctgaaattaa gctgcgcgct aagcaacagc ccacttggaa agatcaaatc cgccaagccg 7201 tagatcacac tatgcagaat cccctcattc gcgattttca ggcctttcaa tccgatttaa 7261 agcaacaggc agtaaaagta tggcagcggg gcaagaacct cacctatcaa cttttaggca 7321 ccaattacaa gtcacgaggg accaaacttg ggcttgatta tgaaaaggag acgattttta 7381 atgagttggc aagaagacaa ttccaatcaa aaaacaacca gcaaccccaa cgagccgtta 7441 acgcaacaaa tgaaccagct caatcaaacc ctgaccgaac tccgcaatta ccagggcacc 7501 cagattcaac tgcaagccac ggccaaaacg tcgttggatc aacaactcca gcagatcgaa 7561 cagactgctc aacaggtcaa tcaccagttt cagacgacct taaacaactt agacgccagc 7621 aacaacagct cacaggccca attaaaacag accttacaaa acgcctacgc agcctttcaa 7681 aagcagacca acctaatcag tcagcaaaat ctgaccgcac tcaaacggat ccaaaccgag 7741 caagaccaaa acaatcagca cctcagccaa ctagacgacc aagtgaacca gaccattcaa 7801 gaaacgatgg cccgagtcgc taaacaggtg gatcagcaat ttcaaaccac ccaaaaacgg 7861 ttctcttggt ttgaaattaa aaattatttg ctggcggtga ttccaactgg tttgttgacg 7921 ggactagttt tttggctcct aaccaaattt ctcagttagg taaaacggat atacaagtgg 7981 ctttgtttca caaactgcgt cacatatttt cttaagttta atcatggtta ttttgcttct 8041 cttgattaat aaacatgatt ttaaagctgc cttagcttat ttagcttatt attggttcaa 8101 aattcatttg acagccaatt taaatcaatc ttggtataaa tatgtgtcaa gcagctaaaa 8161 tctcttagaa acgattttac agccttttag gattagtagt acaaccaact gttgtcggct 8221 ggtttttctt ctccggggtg ctcatcataa tatcttctag ccgccttctt attccagtag 8281 ttggcaaaga ggttttgcat ggtgccgtat aaataattct ccacgtcttt aatctgcttc 8341 tcgttacttc ttaaggcatt aaagtaacgt cttaaggtct tagtcattaa aggctgtaac 8401 tcgggatcat ctagtggaat taagacccct atgtcctggt ggtctttttc aacgcggtat 8461 ttagcattta agataatgcc gataaagcgc cgcatttgtt gtggggttcg gcaccaaaaa 8521 ctaagcagtt ggacggcttt gggttctaag aagacgggta gcccaccgtc tttgtcagtt 8581 aagaactcat tggcatgttt aaccagatct tggttttgtt gttcaatttc tgatgatgag 8641 aaattagttg tggaaaagtc caacttttga gtatctatat tgtatctatt agtatctatg 8701 tttttaaagt ctttatatag attgtgtccg attttcggat tttcgcttgt agcaagggtt 8761 tgtggggtgt cgtcaacgaa ctttcgcgaa cgtccgattt tcggattttc gcttgtagca 8821 agggtttcaa cggtctcctg cgaacgtccg attttcggat tttcgcttgt agcaagggtt 8881 tgcggctctt tttgagcata ttcaccgcgt aaatagacat cggttggctg catatctagt 8941 tcggctaggt aaagtcgatt gggttcgttt ttccctgttt tgggattaaa atgcatagct 9001 ttttgataaa gtagcccagc attttctagt tctttcttga cgttggctaa tttatcattt 9061 gagcagttga acaaatcttt aagttcttga ttggtaaaaa taaaatagat gtgcccctct 9121 tcatcaaccc agtggttgcg taaggaatac tctaaccggt cttttagcac catataagct 9181 aacttagcag tatcgcttaa ctttcgatat tgttggccat acattaatac tttgggaaac 9241 tgaaagaaca aggccctata aacgttgtca gcttgataaa acttaaaatt tgcttgatcc 9301 attataaaaa ctccctttct atatccaacc catgctggct caaaagagag ttgctaaaac 9361 atctgacttg ctttaaaata caaatctgat atgctctagc tgaattacaa agctttcatt 9421 ggtctggcgg ctttataatt catcagcatg gattctcttt cttggttgcc cattcggcaa 9481 cttttttatt ttattcaaca atcaaaataa aaatggacta ggcagccttg ctagctactt 9541 agtccattga atttaatttg tttttaacta tccttcactt gtcccctggg actggtttgc 9601 ggtataatta acctacaaat taagaacaat tttcagtcga ttttaacttg gcggtgaaaa 9661 tcgactgaat ctaagtagct gtctggtagc tactttctaa taagcggaaa agatcttgat 9721 ccctggtggg ttgggatctt tttcgtttat tagcctgttt tttatccagt tgttaaatta 9781 atcttagttt agcatagcgc ttaccagccg gcaaacccta attgtggggt aatttcactg 9841 attggttagt ttgattaaat gatttttgaa caaaaaacga caagaacgac aagcagattt 9901 tgtttttagt tgtcgattgg cgatcttgtc gtttttaact tataatttaa gacggattat 9961 tgaggtggtg aaactattgg ggaagacaat tcgacaactt tcggaagaat tgcagttatc 10021 aaaacaagct attaatcagc gtatatctag tattaaagac tttcgaagca agcacaccca 10081 taaagttaaa aatcatctgg aaatagacga gcagggtgtt aaaatgcttg ctaatttcga 10141 caagcaaaag cgacaagatc agcaagtaaa tcgacaagaa cgacaagccg aaaacgacaa 10201 gcaagataaa aagcaaacta acattaatga tgttttgctg aagcaacttg atgttaaaga 10261 tcagcaaatt tccaaattac aaaagtcctt ggatcagcag caacagctac agttagcgac 10321 acttgcggaa aatcggcaat taaaaggtca tatccaaaaa ttgaatggtc ttcttgaatc 10381 ttctaattca actcaaaaac gacaagccac caagaaaaat gacaacttgc cgaatagtgt 10441 taaaccccat aatatcaagg ataaaaacga caagcaagat agaaatagtg ttgttggtgc 10501 tggcaaaatg caaagaaaaa tacataaaaa taaaaccaat aagagttggt ggcatttttg 10561 gtaatactaa gccaaattct aaatttattt tcgaaattaa ttattaatag aaggtttgaa 10621 ttatttgtcg taacgagttg gcatataaaa attccttcct tttgagagac gatttattca 10681 ttatacgctc tcttaaaagt tgtctcagga atcagcttac atccagttca ctttattgac 10741 ggtaagggaa tcaccggcat tttaaacgct attggcatgt acgaaatttt tcttcaagtc 10801 accaataaaa ctggtgaaaa aatagcaatt acagtcttta agaacgccat taaataaatt 10861 aactgaaaaa atatgaaata gagggcaata aaatgtattc acgtataaag atagctagcg 10921 tatcttgtct atgtatcttc tccgctttga tgttaaccat agcatcaaac accttaaaca 10981 aatacaattt actgctcttt ttaggaagtg gcatatccct gctagccaca attatactgt 11041 ttggaatcct ttttcgaatt aaaaaatatt aaataggttc cataacaaaa gagatgactt 11101 caaacgcagt tgtgcaagta acatttgcgt gactaatgct agtaattctt gctaggattg 11161 ccttagatcc ttgattatga tttaggagga gtgagatttg agctttaaag aagatatcaa 11221 gaccttgcgc aggcaatcta atttaaccca agaagcgtta gcccaacaat tgcatgtaac 11281 ccgccaaaca gtctcaactt gggaaactgg caagaacatg ccaaatttag agaccctgca 11341 tgctttgagt caattgttta acatctcact cgaaaaactt ctatttaacg aggagattac 11401 aatgaaaaaa gataaagacc cctctttggc cacccagata gatcatgatg ttaagcttaa 11461 aagtcgttat cgtcgttgga cttttggttt aggtggcttg attgcactag cactggttag 11521 tattggtatt ttatgtttgg gatactataa aggtattggg acgattgatc gatttgatcc 11581 gtttttatcc tataaagtcg ggtacactaa attacctagt gaaaaggaaa tttcgcctaa 11641 caataaggca accaatggtt actggaccgc ttggttcact gacaatacga tggggaatga 11701 atggaccaaa ctaaccttaa cgacggggct taatcctggg gtcaaaaatc cttatgtgat 11761 ggcttatcat aagggcagtt atgttaaagt tgcgcgtatc gttcctcgca cctacattaa 11821 tcagacttat gttagcaacc tggcagcgct agatgccttg ttaaatcata agggaaatac 11881 agcaactaac aatcatgacc ttaagaagta taagacacaa atccacatat cagacactgt 11941 ccaacagtta gtaactgaat agagaaccac caagtcacaa tccggtaagt ggctttaggg 12001 tcaacttcaa ataacgccta taaaaagggc aagcagagaa tcattgcttg ctcttttcgt 12061 gttttatagg cacaattatt ttgaaatcag gaggatattt atgaaatttg gtgatcgtct 12121 aaaaaaggga agaacagaat tgaatcttac tcaggaacaa gttgctagag atttctttat 12181 tactagacaa accatttcta gctgggaaaa tgaaaaaact tatcctgaca ttatcagctt 12241 aattaaatta agtgactact accatgtttc actagatact ttgttaaagg aggatacagg 12301 tatgcgtgag tttttggaaa agaaagacgt tacaagaaaa ataaaaccaa tttatcgcaa 12361 tcttatagtt attgatttac tagtctgttc attactactt ggagattttt ttaatctaat 12421 acatttaggt gtatttatac tgccaatatt tcttttgtta ttgtgcagtg tatctgcact 12481 aaacaagcta aacgctttca acaattctag ttctcttgga ttaaaataca cttggcaaaa 12541 atatctatct ggagaaaaag ggcttaaata ttctcttgtt atgccaacat tatttataat 12601 ttcaggagtt gcttttcttt tattaaaaga actgtatatt ggtggaatca tcataatagc 12661 aggagcttta cttatatttt ttatttttac gcaaaaaaaa gattaataat gtcactcata 12721 tattataggg tccataatta acaaatcgcc cctcaaaaac attgaaagaa taacccccaa 12781 tatctataat gtggatattg ggggttattt atcataatat ttgatttata acgcatatta 12841 agtcactagt ttttccggga attagattta ccgctcattt caagattacc actttcataa 12901 tgggcccaac atgaatagat ttcgactatt ttagttactt tatcaatggt ataaacgaca 12961 cgatgctgtc catttattct tcgagaatag taaccagccg caggtggtgt taatttttca 13021 aatgactgta ttggtttata tggatcagat tccaatacat tttttatttc ttcaaatgac 13081 tgacgtaatg ggcttcttaa aacttttttt aaatcacctt tagctgatga ttttattttt 13141 actttccaac gattactcat gatcaatttc tttgatcatt tcgtctaaat caaccgattc 13201 atcatcttta cggctcaagg tagcttgaat ttgaccattc atcattaagt tcatggtttc 13261 ctgtaatgcg tcatagtctt tttttccaat caaaacggca ctacggctgt cattggatcc 13321 tgcaataata acaggttggg agtcccgatt agcgtttttg atcagtgaaa atagattggt 13381 tcgtgctgta gttggattaa taattttctc cat //