LOCUS       NC_003080              14323 bp    DNA     circular BCT 09-FEB-2006
DEFINITION  Corynebacterium jeikeium K411 plasmid pKW4, complete sequence.
ACCESSION   NC_003080
VERSION     NC_003080.1  GI:15320554
KEYWORDS    .
SOURCE      Corynebacterium jeikeium K411
  ORGANISM  Corynebacterium jeikeium K411
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Corynebacterineae; Corynebacteriaceae; Corynebacterium.
REFERENCE   1  (bases 1 to 14323)
  AUTHORS   Tauch,A., Kaiser,O., Hain,T., Goesmann,A., Weisshaar,B.,
            Albersmeier,A., Bekel,T., Bischoff,N., Brune,I., Chakraborty,T.,
            Kalinowski,J., Meyer,F., Rupp,O., Schneiker,S., Viehoever,P. and
            Puhler,A.
  TITLE     Complete genome sequence and analysis of the multiresistant
            nosocomial pathogen Corynebacterium jeikeium K411, a
            lipid-requiring bacterium of the human skin flora
  JOURNAL   J. Bacteriol. 187 (13), 4671-4682 (2005)
   PUBMED   15968079
REFERENCE   2  (bases 1 to 14323)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-AUG-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 14323)
  AUTHORS   Tauch,A., Bischoff,N., Kalinowski,J. and Puehler,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUL-2001) Department of Genetics, University of
            Bielefeld, Universitaetsstrasse 25, Bielefeld D-33615, Germany
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF401314.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..14323
                     /organism="Corynebacterium jeikeium K411"
                     /mol_type="genomic DNA"
                     /strain="K411; NCTC 11915"
                     /db_xref="taxon:306537"
                     /plasmid="pKW4"
     gene            181..1746
                     /gene="repA"
                     /locus_tag="pKW4p01"
                     /db_xref="GeneID:1237913"
     CDS             181..1746
                     /gene="repA"
                     /locus_tag="pKW4p01"
                     /note="replication protein"
                     /codon_start=1
                     /transl_table=11
                     /product="RepA"
                     /protein_id="NP_203141.1"
                     /db_xref="GI:15320555"
                     /db_xref="GeneID:1237913"
                     /translation="MTIPDQTGSVVSQGLDPNGTVKNFRGTPHTASSSMSTATWGAAR
                     RIAGTLGGRSTVLGSFGASETDRQHLLAHVGRKTLQGAVTRDFKTAWIKDADGTTVPK
                     LYRVETDAMRRCQYVVLTHKQRASVVVIDIDRRGHSGGRVEDIDSKVYDKLSLLAAGN
                     ISPAWIGVNPINGKCQLIWLIDPVYADSRADSANIRLMKLVTTMLGDHLGGDAAFAHR
                     LSRSPFYNGDDPTAYRWHVQHHRIDRLSHLRDEVRTLTGQPAPERSTPAKQNFSSGRE
                     LINAVRSRREQAQQARDILSSLENDLPSAEVLDGDRIDGVKVLWISEGRAARDETAFR
                     HALATGHRLREAGERMTDAKIIDAYERAYTVAQAVGADNRELEMPPMRDRQTMARRVR
                     GYVLGNKRPSSSGTPLGGAGSATARERKALATMGRKGGQKASERWNDRNSNYAQAETE
                     KLAKANLQRATGGRVTARRIANYFDDTMLQTGSYPSIPDAMEEFGVSRPTVNRALKKA
                     GISLPRGRRKGRK"
     misc_feature    1758..1779
                     /note="22-bp box element of corynebacterial plasmids"
     gene            complement(2710..4164)
                     /gene="blsF"
                     /locus_tag="pKW4p02"
                     /db_xref="GeneID:1237914"
     CDS             complement(2710..4164)
                     /gene="blsF"
                     /locus_tag="pKW4p02"
                     /note="hypothetical 52.6 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="BlsF"
                     /protein_id="NP_203142.1"
                     /db_xref="GI:15320556"
                     /db_xref="GeneID:1237914"
                     /translation="MELKNSKRGILLEIVSLLPNSIPVYSILFGFMFVADGVWFGTLV
                     VSAVYYSWTRVYRILISTVGISGWATDAGISIGRGISSKRYISSKWAGVSGVEIEENL
                     LLRWLGCKRLKVYFAGSSLETAVFCCLSPENAYAVRDRFRLVSIPDDAPDRDSTAVSK
                     FTEEAERGSEVSLSGFRLGVAALSSGRFLLVLPFLLSVTNTLGISFIGEESIGVFVSS
                     GGVLAATLKVFLTSLSLVAVGIVFFVVLYHGWSVCVSGGGIRVSYGSFNRKDTVVHAA
                     DVQAVFLTRTIAYSAVKAWRLSVQCRSSDEGSRVRLISPLIRDTELDDVLDKLGVRGS
                     RMVRNGISSRSVSLASHCRSAIFPFVLLVGSCCLCAQLVVNRDLFLAGAIVSAIVACL
                     FVVWLALQSASIGECANGHCILSRSGLFRFRVCVFYLDSIDSWKVVEWFKRNPVFSLF
                     ILGFNVSGIKKRVFASRSAPVSRNIADALEAGVT"
     gene            complement(4168..4626)
                     /gene="blsE"
                     /locus_tag="pKW4p03"
                     /db_xref="GeneID:1237915"
     CDS             complement(4168..4626)
                     /gene="blsE"
                     /locus_tag="pKW4p03"
                     /note="hypothetical 17.1 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="BlsE"
                     /protein_id="NP_203143.1"
                     /db_xref="GI:15320557"
                     /db_xref="GeneID:1237915"
                     /translation="MQPRHLRITSSVCKREYITSALGLLLFAAAFTLLYSLDVLWSRE
                     EWFILVCAIIACVDIALSSVAPILKKKTTEVRIDDLSITLTKGILIRTRETIPRSNVT
                     MVVRSVNPFDRRWGHEKVTVKASSTELRLPVLPSGSAVDISRMLGIEFER"
     gene            complement(4635..5540)
                     /gene="blsD"
                     /locus_tag="pKW4p04"
                     /db_xref="GeneID:1237916"
     CDS             complement(4635..5540)
                     /gene="blsD"
                     /locus_tag="pKW4p04"
                     /note="ABC transporter ATP-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="BlsD"
                     /protein_id="NP_203144.1"
                     /db_xref="GI:15320558"
                     /db_xref="GeneID:1237916"
                     /translation="MTKVVETRAVKKTFRGTGNVLNGVDLHVNESEVVGLLGPNGSGK
                     STLLKIMVGLLAADGGKVTFWGKGYDNLESPVNRIGVLLSPEWVDERLTVEDFVTSQL
                     ILIKIQSSSRKKICKEILREVGLSGSEKRKISQLSLGMRQRVCLACCFASNPDVLILD
                     EPLNGLDADGVLWVQDLIRSHRDSGGSVLLSSHLMAEMQTVADTIAILNGGKIVARGT
                     IDSLSGERRSLISTDDNPRDLVSVYKNEGYSDVVLDGEKVSVGGISPSEAARLAFSNG
                     FSISGLSETTKSLEEIYRSVVGSRE"
     gene            complement(5537..6280)
                     /gene="blsC"
                     /locus_tag="pKW4p05"
                     /db_xref="GeneID:1237917"
     CDS             complement(5537..6280)
                     /gene="blsC"
                     /locus_tag="pKW4p05"
                     /note="hypothetical 26.4 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="BlsC"
                     /protein_id="NP_203145.1"
                     /db_xref="GI:15320559"
                     /db_xref="GeneID:1237917"
                     /translation="MNTILSRVHTFTHTRVGRFSFAIATIILLAVSLSSAHKVKAGEI
                     ADVSELFSGGNSFALFIVGMGMTIFQASEYNSGGMPYILMRVPNRIEVAKDSLATSAV
                     ISIGYALIANVFTVAVSLAYLTFSGTIQEISYDTSSILLTMIGTIFSYLIVGIIAFTT
                     GDITQSTAGGVFIYFVIYWVLPLSGALVTAIRGEIGNALVQYSLASNVEKLLTTSGTA
                     FIASMLIISAWAVLISIVGFAQFRRYSPK"
     gene            complement(6296..6580)
                     /gene="blsB"
                     /locus_tag="pKW4p06"
                     /db_xref="GeneID:1237918"
     CDS             complement(6296..6580)
                     /gene="blsB"
                     /locus_tag="pKW4p06"
                     /note="hypothetical 10.2 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="BlsB"
                     /protein_id="NP_203146.1"
                     /db_xref="GI:15320560"
                     /db_xref="GeneID:1237918"
                     /translation="MKMTTLIIICALAAVAGLQYFLPRFGPNILGAVIPILFAVAAVI
                     LLMNNGVDRIRDILLPLAGFFALLCIWGGAIEAKKAKTEDEMEKIDRQIS"
     gene            complement(6577..6855)
                     /gene="blsA"
                     /locus_tag="pKW4p07"
                     /db_xref="GeneID:1237919"
     CDS             complement(6577..6855)
                     /gene="blsA"
                     /locus_tag="pKW4p07"
                     /note="hypothetical 10.6 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="BlsA"
                     /protein_id="NP_203147.1"
                     /db_xref="GI:15320561"
                     /db_xref="GeneID:1237919"
                     /translation="MVTKWIQNLSQSDLALLKNFVVQSGNIKSLSAQYSVSYPTMRAR
                     LDTLIEKIKIGDEEPDTFIAQLQAYAIDRKVPSQFVQEIAEIYYTRKE"
     gene            complement(7462..8259)
                     /gene="ykwA"
                     /locus_tag="pKW4p08"
                     /db_xref="GeneID:1237920"
     CDS             complement(7462..8259)
                     /gene="ykwA"
                     /locus_tag="pKW4p08"
                     /note="hypothetical 29.5 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="YkwA"
                     /protein_id="NP_203148.1"
                     /db_xref="GI:15320562"
                     /db_xref="GeneID:1237920"
                     /translation="MTYDYWRPSQEQRDKVNEVASDRRPELLEESYREALAWLEDVDE
                     FSPTPDPAMATILKRALSRVQFYNQTVPDVDLPSPQWTPVDDLVLNGGVAKEWIASLH
                     TVHNIPTANSRDARQVRALLHALGHDVPSFLREQYQVASQGEAGVYCMVPDDRANVLA
                     VRPTSCRYLDTTGASVETHRDPSRGGNLAVFLRLNAGVLTLLPHESRHSGVQFGYSGT
                     GPRNLANDIVNAYPAASTLTDNQRDSETDRVFQEISVDGLTALMIHL"
     gene            complement(8375..8641)
                     /gene="ykwB"
                     /locus_tag="pKW4p09"
                     /db_xref="GeneID:1237921"
     CDS             complement(8375..8641)
                     /gene="ykwB"
                     /locus_tag="pKW4p09"
                     /note="hypothetical 9.2 kDa protein"
                     /codon_start=1
                     /transl_table=11
                     /product="YkwB"
                     /protein_id="NP_203149.1"
                     /db_xref="GI:15320563"
                     /db_xref="GeneID:1237921"
                     /translation="MTTSSHAADAAVTLIIVSCAPVRSTAYCLTPWRRGRRLTQSFPG
                     RSDCSDRRSAAASLVSRCCGSSIADMLRITTAPRSAALADQPGA"
     gene            complement(8753..8911)
                     /gene="aucA"
                     /locus_tag="pKW4p10"
                     /db_xref="GeneID:3342454"
     CDS             complement(8753..8911)
                     /gene="aucA"
                     /locus_tag="pKW4p10"
                     /codon_start=1
                     /transl_table=11
                     /product="aureocin A53-like protein"
                     /protein_id="YP_220784.1"
                     /db_xref="GI:62420831"
                     /db_xref="GeneID:3342454"
                     /translation="MAGFLKVVKAVAKYGSKAVKWCWDNKGKILEWLNIGMAVDWIVE
                     QVRKIVGA"
     gene            complement(9390..9698)
                     /gene="ykwC"
                     /locus_tag="pKW4p11"
                     /db_xref="GeneID:1237922"
     CDS             complement(9390..9698)
                     /gene="ykwC"
                     /locus_tag="pKW4p11"
                     /note="hypothetical 10.9 kDa protein; similar to
                     N-terminal region of IS1201 transposase"
                     /codon_start=1
                     /transl_table=11
                     /product="YkwC"
                     /protein_id="NP_203150.1"
                     /db_xref="GI:15320564"
                     /db_xref="GeneID:1237922"
                     /translation="MTTVTRRDPADKAEIDAIEKKLLANPEIAKLIDDLGTSTTDAND
                     LVRGMLQASITRGINAEMDVHLGYEPSDREGKTAAGTDNHRNGIYPKTVDSNYGAGNC
                     "
     repeat_region   9762..9929
                     /note="IRKW4a"
                     /rpt_type=inverted
     gene            9942..10595
                     /gene="ypkD"
                     /locus_tag="pKW4p12"
                     /db_xref="GeneID:1237923"
     CDS             9942..10595
                     /gene="ypkD"
                     /locus_tag="pKW4p12"
                     /note="hypothetical 25.2 kDa protein; similar to YpkD from
                     Corynebacterium jeikeium plasmid pK43"
                     /codon_start=1
                     /transl_table=11
                     /product="YkpD"
                     /protein_id="NP_203151.1"
                     /db_xref="GI:15320565"
                     /db_xref="GeneID:1237923"
                     /translation="MDNPLESTRLHCVECGMQLFYAGVGRKPRYCSQTCRSRAWEKRR
                     AAREGLISQEVVDRPVEVYKPIDAEQVAQWLSGHPRRLSAVLKLLEWTDEHLEVFRRG
                     LEQSTEELSLIPTAEKERLESASQKAFRFKHDLASWQRRLRTQREENAALRQELEQCK
                     SVKVPTPVAEKRHPAEVAPMPTFSGEAKTVKVEGQQVTVPARWSRKQIRQWMRSNGR"
     repeat_region   10613..10780
                     /note="IRKW4b"
                     /rpt_type=inverted
     gene            10914..11531
                     /gene="resA"
                     /locus_tag="pKW4p13"
                     /db_xref="GeneID:1237924"
     CDS             10914..11531
                     /gene="resA"
                     /locus_tag="pKW4p13"
                     /note="resolvase"
                     /codon_start=1
                     /transl_table=11
                     /product="ResA"
                     /protein_id="NP_203152.1"
                     /db_xref="GI:15320566"
                     /db_xref="GeneID:1237924"
                     /translation="MTNETDLSLPLELNEHQHVVTGQLVGYARVSTTGQNLDRQVAQL
                     QKAGATEIYKEKISGASRERPQLEEMLRYLRKGDQLIVTSMDRLARSFLDLHNIIDDL
                     ISRGVSVRFLRESQTYSSHSDPVAVLMLGVLGSVAQFERAIMRERQAEGIAQAKKRGA
                     YKGRAPAMNEASIKQAREMIDMGVPKADVARRLGVSRATLYRYLP"
     gene            12069..12965
                     /gene="repW"
                     /locus_tag="pKW4p14"
                     /db_xref="GeneID:1237925"
     CDS             12069..12965
                     /gene="repW"
                     /locus_tag="pKW4p14"
                     /note="IncW-like replication protein"
                     /codon_start=1
                     /transl_table=11
                     /product="RepW"
                     /protein_id="NP_203153.1"
                     /db_xref="GI:15320567"
                     /db_xref="GeneID:1237925"
                     /translation="MTISLPALSDDDDGQTVDYTNRIFVQALFPYRKSDEYRRAITQG
                     SKEVIISSPNGLPYGKYPRLIMAYIITTAVARAHQVEQGLMDSDEARQIPLGESLNEF
                     FRRIGVVARGTGGSRGTVTRIREQLVRLASSSIVVRSRIKKGRVDIHWGVNHPIAGEW
                     EPWFDADNPDQAAIQLTDRFFQLIADAPIPIDLDILHKLGKPRAMDIYVWITVKKARL
                     NYQNRPSFTFSWKQMEHQFSPKELTTWAQRANFRKEFNGCLETIRALWPDVGVDTDTK
                     AGVTLHKSAPSVTMRPSRKQLR"
     gene            13326..13910
                     /gene="parA"
                     /locus_tag="pKW4p15"
                     /db_xref="GeneID:1237926"
     CDS             13326..13910
                     /gene="parA"
                     /locus_tag="pKW4p15"
                     /note="type Ib partitioning protein"
                     /codon_start=1
                     /transl_table=11
                     /product="ParA"
                     /protein_id="NP_203154.1"
                     /db_xref="GI:15320568"
                     /db_xref="GeneID:1237926"
                     /translation="MRVSFVHTKGGVGKTTSAIMVAAAATRHGRAVEVFDTDPQGSAS
                     RWAEIAEGRGDTLPFPVRYLTANELRQLPADESTLQIVDTPPGEAASIQAAIDTADLV
                     VVPSGASPMDIDRVWPTIETITGHPAGVLLTGVLMHTRFYTEARHLLEDQGVATFYNA
                     IPQREEIKAAFGTNPIRFHGYDDVYQEISEVEEL"
     gene            13910..14149
                     /gene="parB"
                     /locus_tag="pKW4p16"
                     /db_xref="GeneID:1237927"
     CDS             13910..14149
                     /gene="parB"
                     /locus_tag="pKW4p16"
                     /note="type Ib partitioning protein"
                     /codon_start=1
                     /transl_table=11
                     /product="ParB"
                     /protein_id="NP_203155.1"
                     /db_xref="GI:15320569"
                     /db_xref="GeneID:1237927"
                     /translation="MAEKRAHLADTLSKGRVIKKTKPVPVADTFANKDVALDRRTTIY
                     LSQDNWKALKLRSVEEDKNLSELINDLVADYLSAK"
ORIGIN      
        1 tctagagccg cgtaggtgaa tgctccccct ttaaggaagc gtcgtggata acggcgcgta
       61 accgcccaaa acacacgcat gtaatttaag ctggtcgaaa cgaaaaaatg agcgccgaac
      121 cggcggctac cagttcgacg ctcgctttac ccccagtccc acctgggaga aagcttgagt
      181 atgactatac ctgatcaaac cggatcagtt gtttcacagg gcctagaccc aaatggaaca
      241 gtaaaaaatt ttcgcggcac accccacacc gcgtcttcat ccatgtccac ggccacgtgg
      301 ggcgctgcac gtcggattgc cggcactctc ggcgggcgta gtaccgtcct cggctcgttt
      361 ggagccagcg agaccgaccg gcagcacctt cttgcccacg taggccgtaa aacgctgcaa
      421 ggcgctgtca cgcgcgattt taaaactgcg tggatcaaag atgccgacgg caccaccgtc
      481 ccgaagctct accgggtaga aaccgacgca atgcgccggt gccagtacgt cgttttgacg
      541 cataagcaac gcgccagcgt tgttgtgatc gacatcgacc gccgtggaca ctccggcgga
      601 cgcgttgaag atattgactc caaggtctac gacaagcttt cgctgctggc tgcggggaac
      661 atcagtccag catggattgg cgtgaacccg atcaacggca agtgccaact aatctggctc
      721 atagaccctg tctacgccga cagtcgcgcg gactcggcaa atatacgcct catgaagctg
      781 gtcaccacca tgctgggaga ccacctcggc ggagatgccg cgtttgccca ccggctgtca
      841 cggtcgccgt tctacaacgg ggatgatccc actgcgtacc ggtggcacgt ccagcaccat
      901 aggatcgacc ggctatccca tctacgcgac gaggtgagga ctttgactgg acaaccagca
      961 ccagagcgtt caacgccagc gaagcagaac ttctctagcg gacgtgagtt gattaacgct
     1021 gtgcgcagtc gccgtgaaca agcacagcaa gcccgcgaca ttctgtcctc gctggaaaat
     1081 gatttgccta gcgctgaagt tttggacggt gaccgtatcg acggggtgaa ggtcttatgg
     1141 atctctgagg ggcgtgcagc ccgtgacgag accgcgttcc gccatgcact ggccactggc
     1201 caccgtctcc gcgaagcagg ggagcggatg acggatgcaa agatcatcga cgcctacgaa
     1261 cgtgcctaca ccgtcgccca agctgtgggg gcagacaatc gcgaactgga gatgcctccc
     1321 atgcgggatc gtcagacgat ggctcgtcgc gtgcgtgggt atgtcctcgg caataaacgc
     1381 cctagtagtt caggaacacc tctcggaggc gctggaagcg ctacagcccg cgaacgcaag
     1441 gcactagcca ccatgggacg taaaggcggc cagaaagctt cagaacgatg gaacgaccgc
     1501 aacagcaact acgcacaagc cgagactgaa aaactagcca aggcgaacct acagcgtgca
     1561 acagggggac gtgtcaccgc gagaaggatc gctaactact tcgatgacac catgcttcag
     1621 acaggctcgt acccatcgat ccccgatgcc atggaagagt ttggtgtgtc gcgccctacg
     1681 gtgaatagag cactcaagaa ggccggaatc tccctccctc gagggcgaag gaaggggaga
     1741 aaataaatgt gtcaggccgt aagcaataca cggttcccct gccccgttag ggcagttaat
     1801 ctcttatccc cgcacacacc ttgacggtgc cgactgtccg tttcgtttct gcggaagaca
     1861 ccgggcgtag atggttgggg cgctgtagat ttgatcgtga ggggcgatcc cccgaagtct
     1921 ctctcgcttg cgaccgccgc gttggagagt gtctgatggt aatcgttgcg gggcagccat
     1981 gcgccgacaa ggcgcaagat gccttccgtg tcgctgacgt gcagtacccc tgactccgac
     2041 cggaatagcc ggttagtgtc attggtcatc gctcacggct aggcccaacg ccgggtggcc
     2101 gaacgtttca gcgcctcatc aagcactgcc tatcgctggg tgacccgcca ttgcgtcggc
     2161 gaatcgctat ccgactgcac ggggaggcca cacagccggg ccgccggatc aacaggcaac
     2221 ggttcatccg tcgctacgga cacaccacac cgaccactac ctcggtatcg ctcgctcctc
     2281 cgtcagcccg ataccggaca actacgacaa gcctgaactg cattgcacca atcaagccac
     2341 cgggccgccg ttgcacaaag ccccaccgct acgagaaggc cgacccggag acctagcacc
     2401 tcacgcagca agaaactcgg gaagattctc ggcggggcgc attctgaagg ttcggcaaag
     2461 gctccgccca acaccagaaa ctccgctgga cctgcgggca gcggcacact ccagaaaacc
     2521 tcgtcgcgag actacaggca cctgcaccag gggtgcatct accgatactc aaaagtggat
     2581 tccgcaaatc acctctgcga caactaaaaa ggcaccactt cgaggtccta gcccggacca
     2641 ggcgcctttg aaaacactat agtaaatgtg cacctgttcc actaacaatg acggtgcaaa
     2701 aatacgacac tacgtcacac cagcttctag tgcgtctgcg atatttcggg acacaggggc
     2761 actccgcgac gcaaatactc tcttcttaat tccagagacg ttaaacccca agatgaacaa
     2821 agagaataca ggatttctct tgaaccactc aaccactttc cacgagtcaa tagagtccaa
     2881 atagaaaaca caaaccctaa agcggaagag gccagaccta gacaatatgc aatgaccgtt
     2941 agcacactca ccgatactgg ccgactgtag cgctagccac acaacaaaca aacacgcaac
     3001 aatggcagat acaattgctc cagctaaaaa tagatcacga ttcactacta gctgcgcgca
     3061 caagcaacac gaaccaacaa gcaatacgaa gggaaaaata gccgatcgac agtgcgacgc
     3121 taacgaaaca gaacgactgg atattccatt cctgaccatt ctggacccac gaactccaag
     3181 cttgtcgagc acgtcatcca actcagtgtc ccgaattaag ggagaaataa gccgaactct
     3241 actaccttca tcagaagacc tgcattgtac agaaagacgc cacgctttta cagcagaata
     3301 tgcaatagtg cgagtcaaga agacagcttg tacatccgcc gcatgcacaa cagtatcttt
     3361 tctgttgaaa ctcccgtagc tgacgcggat accccctccg ctaacgcaca ccgaccatcc
     3421 gtggtacaag accacaaaga acacaattcc aacagccacc aaggacaggg aggtaaggaa
     3481 taccttcagc gttgccgcta gaacaccacc agaactaaca aaaactccaa tactctcctc
     3541 tccgataaat gagataccca gagtattggt taccgacaga agaaaaggga ggaccagaag
     3601 aaatctacca gatgacaaag cggccacacc taaacgaaac ccgctaagac tgacctccga
     3661 ccccctctca gcttcctcgg taaacttcga aacagcggtg gaatcgcggt caggtgcatc
     3721 atcaggaatc gataccagtc gaaacctgtc tctaacagca taggcattct ccggagacaa
     3781 acagcagaaa acagccgttt ccagtgatga acccgcgaag tagactttta gccgtttgca
     3841 acccagccac ctcagaagga gattttcttc gatctcgaca cctgaaaccc cagcccattt
     3901 agaagaaata tacctcttcg aagatatccc tcttccgata gaaataccgg cgtccgttgc
     3961 ccacccagaa ataccaactg tagatataag tatgcggtat accctggtcc aggagtagta
     4021 gaccgcagat actacgagag tgccgaacca cactccgtcc gctacaaaca taaatccaaa
     4081 caggatgcta tagacgggga tagaatttgg caacaaggat acaatctcaa gtagtatccc
     4141 gcgtttactg ttcttcagct ccattggtca tctctcgaat tctatgccga gcattctgga
     4201 aatatctacg gccgaacctg acggtagtac ggggagccgt aactcggtag atgaagcttt
     4261 cacggttact ttttcatgac cccaccttct gtcgaaagga ttaaccgacc tgacgaccat
     4321 tgtcacgttc gatcggggaa tagtctcccg agtacgaatc aatatcccct tagttagggt
     4381 tatggataaa tcatcaattc gcacttccgt tgtcttcttc ttgaggatag gagcaacaga
     4441 agacaaagca atatctacgc atgcaataat tgcgcagact aatataaacc actcttccct
     4501 ggaccataga acatctagag aatagagtag agtaaatgcg gcagcaaaca gaagtaaacc
     4561 cagcgcagaa gtaatgtatt cgcgcttgca gacactcgaa gttatccgta ggtgtcgagg
     4621 ttgcatacag ccctctattc tctagacccc acgactgacc ggtaaatctc ctccaggctc
     4681 ttagtcgtct cggacagccc actgatagag aacccattgg agaaagcaag acgagctgct
     4741 tctgacgggg aaataccccc taccgatacc ttctctccat ccaatacaac gtcagaatat
     4801 ccttcattct tatatacaga aactagatca cgtgggttat cgtctgtgga gatcagggaa
     4861 cgacgctccc cggaaaggct atcaattgtt cctcgtgcca ctatttttcc gccatttaaa
     4921 atagcaattg tatccgcaac tgtttgcatt tcggccatga ggtgtgaaga caagagtacc
     4981 gagccaccac tatcccgatg ggaacgtata agatcttgca cccaaagtac gccgtctgcg
     5041 tccaatccgt taagcggttc atccagaatg agaacatcag ggttagatgc aaaacagcat
     5101 gccaagcaca cacgttgcct catcccaagt gagagttgcg atatttttct cttctcagaa
     5161 ccagaaagtc cgacttcccg tagtatttct ttgcatatct tcttacgact ggatgactgt
     5221 atcttgataa ggatgagttg tgaagttacg aagtcttcga cagtcaatcg ctcatccacc
     5281 cactcggggg atagaagtac gcctattcta ttcaccggag attcgaggtt atcgtaccct
     5341 ttaccccaga acgttacttt tcctccgtcg gccgctagaa gtcctaccat tatcttcagg
     5401 agagtagact tgcccgatcc gttaggaccc agcaggccga ccacttcgga ttcgttgaca
     5461 tggagatcga ccccatttaa aacattcccg gtcccccgga aagtcttttt tacagctctc
     5521 gtctcgacta ctttagtcat ttcggtgagt acctcctgaa ctgagcgaag ccaacgattg
     5581 atatcaacac ggcccatgcc gaaataataa gcatgctggc tatgaaagca gttccacttg
     5641 tagttaggag cttctctacg ttagacgcca agctatactg caccagtgca tttcctattt
     5701 caccgcgtat agctgtaact agtgcgccag atagcggaag tacccagtag atgacgaagt
     5761 atatgaacac gcccccggca gtactttgtg ttatatcgcc tgtggtgaaa gcgatgatcc
     5821 cgacaatcag atacgagaat atcgtaccta tcatcgtcag taggattgaa gaagtgtcat
     5881 agcttatctc ttgtatcgtt ccgctgaagg tgaggtatgc gagcgaaacg gcaacggtga
     5941 atacgttcgc gatcaatgcg tatccgattg atatcactgc ggacgttgcc agggaatctt
     6001 tcgcgacctc gattctattt ggcactcgca tgagtatgta cggcatacct cccgagttat
     6061 actcagaggc ctgaaatatc gtcatgccca taccgactat gaaaagcgca aagctatttc
     6121 cgccagagaa gagttccgat acatctgcta tttcgccggc cttgactttg tgagcactcg
     6181 ataacgacac tgccagtagt attattgtgg caatggcgaa tgagaatcgg cccactcttg
     6241 tgtgtgtgaa tgtatgcacc ctggagagga tggtgttcat ttatttgtcc cctgtttaac
     6301 tgatttgcct gtcgattttt tccatttcat cttcagtctt ggcctttttt gcttcaattg
     6361 ctccacccca gatgcagagc aaggcaaaaa atccagcaag tggcaggagg atatctcgga
     6421 tcctgtcaac gccattgttc atcaggagaa ttacagcggc aacggcaaat agaataggaa
     6481 ttaccgcacc aagaatgttc ggtccaaatc tggggaggaa atactgaagt cccgctacag
     6541 ctgccaatgc acagatgatg attaatgttg tcattttcac tcttttctcg tgtagtaaat
     6601 ctctgcgatt tcctggacga attgcgatgg aacctttcga tctatcgcat aggcctgcag
     6661 ttgcgcgatg aacgtatctg gttcttcgtc gccgattttt atcttctcaa ttagagtgtc
     6721 tagccgtgct ctcattgtgg gatacgacac ggagtattga gcggagagcg attttatatt
     6781 gccggactga acgacgaaat tcttcagtaa ggcaagatcg ctttgggaga ggttttgaat
     6841 ccacttagtt accatctttt ttcaatccag gtgtgactgg tgtgtttgcg ttcaggttag
     6901 ctttgttgag ctatttagtt ttggacgata tcacgttggc gcgacaccct cgtgaggtaa
     6961 atttcagcta ccccattctg gatatttctc atcttgacat agtgtcccta gcggctttgt
     7021 gaactgcatg tttgcttcca ctttcttaac tgtgatgtgg gtcacactat ggtagcgtta
     7081 cccccatttc ggtctacttc tttcgcggag ttaccacctc ctacactccc gattccatac
     7141 ctggagcttc ccatcattta cgtcactgtg acgtattcgg ctcgcacctc cttaggtatc
     7201 gccgctgtcg cggagagcat cgttttccct ttgcggagca cctactaatg gtttcggccc
     7261 caggggctag gccgtgttgc taaaggggct gacttcatcc agttcaccgt cgccgccaag
     7321 cgcaccccag ggtgaagagc ctttaaacat tgtttatatg agttcaggac gggcacgaca
     7381 gtccttcgct ggtggtgcgg ttcaggcacc gtcgccgagc agccacgact ccaggtcccc
     7441 agtgctgaaa ccggcccaga gctataggtg gatcatcagg gcggtgaggc cgtcgacgga
     7501 gatctcctga aagaccctgt ctgtctcact gtcccgttgg ttgtccgtca gggtactggc
     7561 ggctgggtac gcgttgacga tgtcgttggc gaggtttctg gggccggtgc cgctgtaacc
     7621 gaactgcacg ccgctgtgtc gagactcgtg tgggagaagg gtcaacaccc cggcgttcag
     7681 ccggaggaag acggccaggt tgccccctcg gctcggatcg cggtgtgtct ccacactggc
     7741 cccggtggta tccaaatagc ggcagctcgt cgggcgtacc gccaagacgt tggcacgatc
     7801 gtcagggacc atgcagtaca ctccggcctc gccctgggag gccacctggt actgctcacg
     7861 caggaacgac ggcacatcgt gtccgagggc gtgcagaagc gcccggacct gacgagcatc
     7921 ccgactgttg gctgtaggaa tattgtgcac agtgtgcagg ctggcgatcc actccttcgc
     7981 taccccaccg ttgaggacga gatcgtcgac gggggtccac tgaggtgatg gaagatccac
     8041 gtccgggacg gtttggttgt agaactgcac cctgctcaac gcccgcttga ggattgtggc
     8101 catcgccgga tccggtgtgg ggctgaattc gtcaacgtcc tcaagccagg ccaacgcttc
     8161 cctatacgac tcctcgagca attcgggtcg gcgatcactg gcaacttcat tgaccttgtc
     8221 ccgttgctcc tgcgacggtc gccagtagtc gtacgtcacg gctatgcgtt ccttcagtca
     8281 cggcgggtag agagacagtg gagagtggtc gatcagattg aacatcccac tgacctcatg
     8341 ggcgagctgg gtagcgaact gcgcccgcag cggctcatgc tcctggttga tctgcgagag
     8401 cggccgaccg aggggccgta gtgatcctca gcatgtccgc gatcgatgac ccacagcacc
     8461 tgctgacgag actggccgcc gctgatcgcc tgtcgctaca atcgctcctg ccggggaagc
     8521 tctgggttaa cctccggcca cgtctccagg gggtgagaca gtacgcggtc gacctcaccg
     8581 gtgcgcacga gacgatgatg agcgtcacgg ccgcgtccgc ggcgtgacta cttgttgtca
     8641 cctaatcgtg catcaaaccc gtatggcgaa catattcttc cagcggacat gcaacataaa
     8701 aacataaaag tgcgcccgag cttacgctcg ggcgcacttc cgaagatgaa ggctaggcgc
     8761 caacaatctt acgaacctgc tcgacgatcc agtccacagc cataccgatg ttcagccact
     8821 ccaggatctt tcccttgttg tcccagcacc acttcacagc cttggaacca tacttcgcaa
     8881 cagccttaac gaccttcaga aaaccagcca tcttaaatct ttcctttctg acacgccacc
     8941 tgggacgatt tgaaaaattt cctcatttcc tttccctaac tacactagct tcaaaatctc
     9001 ccgagacaac aggaaggagc gacaaatcaa tagatgaaaa cttttctttc acaatgtatg
     9061 aaagaaattc atcaccgctt tcgcaaagtt aaacgccact gcaagcgtag ggtcctgaac
     9121 tacccccatg tggggtattg tcgaatgcgt gcagcacagt gaacgcaggc aaggtacgga
     9181 ccgagccgag aggcagcacc tccccgaggc ttgagcacgc agagaaacct tatcggcaac
     9241 ccaaatcagt ccgattacct atagctattc gggggatatg gttccccacg ctccgaagcg
     9301 ccgctgcgta acgccctcac tgcctgatgc aggttccagc agacagaacc actcgcaggt
     9361 atcggccaag ccaacgatcg cgtgggacat caacagttac cggccccgta gttagagtcc
     9421 acggttttcg ggtagatgcc gttgcggtga ttgtctgttc cagctgcagt tttaccctcc
     9481 ctatcgctgg gctcgtagcc aaggtggaca tccatttcag cgttgattcc cctggtaatc
     9541 gaggcttgca acatgccccg aaccaggtcg tttgcatccg tcgtagacgt gcctaggtca
     9601 tcaatcagtt tcgcgatttc ggggttagca agcagcttct tttcaatcgc gtcaatctcg
     9661 gccttatcgg ccggatctcg tctcgtcaca gtagtcattc tggtccatct cctcatgcag
     9721 gttgggtacc cacacacaaa ccatcagaca ctctccatcg tgggcagcgc tacaccccac
     9781 cccagcctgt tagacgctcg cgcagatcga tagcagcgca tccacctggg catttgcccg
     9841 tgtcgctatc gctacgggca gtcgcccttc aaattcactc acaccgtttg cacatcatgt
     9901 gtgtcgggtt acgttgtgac gaaatgggtt agtgtggagg catggataac cccttagaat
     9961 ccacgcgcct gcactgcgtt gagtgcggta tgcaattgtt ctacgcggga gtgggacgca
    10021 agccgcgcta ctgtagccaa acctgtcgca gccgagcgtg ggaaaaacgc cgtgcagccc
    10081 gcgaagggtt gatttcccag gaggtcgtgg atcgtcccgt agaggtctac aaacccatcg
    10141 acgcagagca ggtagcccag tggctaagcg ggcacccgcg acggctatct gcggtgctga
    10201 aactcttgga gtggacagac gaacatcttg aggtatttcg cagaggatta gagcaaagca
    10261 ccgaagagtt aagcctgatt cctacggcgg aaaaagaacg actcgagtct gcctcgcaga
    10321 aggcatttcg cttcaaacat gaccttgctt cttggcaacg tcgtctgcgt acgcagcgag
    10381 aggaaaacgc cgcgctgagg caagaactcg agcaatgcaa aagcgtgaaa gtccccacgc
    10441 ccgttgcaga aaagcggcac cctgctgagg tggcaccaat gcctacgttt agcggtgagg
    10501 ctaagaccgt caaagttgaa ggccaacagg tcactgttcc ggctcgctgg agtcggaaac
    10561 agattcgtca atggatgcgg agtaatggac ggtaaactcg gtaaaaaaat tgacctgttt
    10621 tgtcacaacg taacccgaca cacatgatgt gcaaaaggtg tgcgtggatt tggagggcta
    10681 gtgcccgtag cgagttcgat acgggcaaat atccaggtgg atgtactgct attgatctgt
    10741 gtgagcggct agcaggctgg ggtggggtgt agcgctgccc gcaatgtatg tgaggataaa
    10801 tctgcgcagt ctgacctacg caaacacgaa cttctcgcaa gagtgtcttt ttagggcatg
    10861 ccaaatgaga cactttcgag ttacagggaa agctgttgct ttagggttgg tttatgacca
    10921 atgagacaga tctgtcgcta ccgcttgagc taaatgaaca tcagcatgtc gtcactggac
    10981 agttggtggg gtacgcccgt gtaagcacga cgggtcagaa tttggatcgt caggtcgctc
    11041 agctccaaaa ggcgggggcg accgagatct acaaggagaa gatcagtggc gcgtcccgtg
    11101 agaggccgca actggaggag atgctgcgct atctgcgtaa gggggatcaa ctgatcgtca
    11161 cgagcatgga tcggctggcg cggtctttcc tcgacctgca caacatcatt gatgacctca
    11221 ttagtcgggg agtgtccgtg cggtttctgc gggagtcgca gacctactcg tctcacagtg
    11281 acccggtggc cgtgttgatg ctcggtgtcc tggggagcgt tgcgcagttc gagcgggcga
    11341 tcatgcgaga gcgtcaggct gaggggatcg cgcaggcgaa gaagcgcggc gcatacaagg
    11401 gaagggcgcc ggcgatgaac gaggccagca ttaagcaggc gcgagaaatg atcgatatgg
    11461 gagtacccaa agcagacgtt gctcgccgtc ttggtgtgag tagagcgact ctttatcggt
    11521 atctccctta gtcttcatga gggtaaatct gcgcagcctg gcaacgctat tgctgaccag
    11581 gcacgccaga ggtagcagac agtacgcatt caccatcgag cgccagcgtc aagagccact
    11641 gtttgagaac tactccaagc taacgtcata acgctataac gctaacgtta tgacgttgcg
    11701 acgctagaac gctagaacgt gataacgttg tacgcaggta gacggcaaca aaaatgaatg
    11761 gtgatacatg agagtatcgt tcgtcccctc gggtgcatcc cccgagtgtg tggccaacga
    11821 tagaaaccat tactggccac cccgccggcg tgttgcttac cggtgtactt atgcacaccc
    11881 ggttcgagtc cggggtgcgc accttctctt aaatagggaa atagggaaaa ccccgcaccg
    11941 tagaggcggc aacctctagc gggggtttga agcgagactt tccggccctc gttgttggat
    12001 gtatctcatt aggacgcgat atacagcaac ggctgaaaac cttcgtacag ataaaggagt
    12061 acctatccat gacaatcagc cttcccgccc tatctgacga cgatgacggt cagactgtcg
    12121 actacacgaa ccggattttc gtccaagcac tgttccccta ccgcaaaagc gacgagtacc
    12181 ggcgcgcaat cacgcagggc agcaaagaag tcatcatcag ctcccccaac gggttgcctt
    12241 acggtaagta ccctcggcta atcatggcct acatcatcac tactgccgtc gcgcgagcgc
    12301 accaagtcga gcaagggctt atggatagcg atgaagcgcg tcagattccc ctcggggagt
    12361 ctctcaacga gttcttccgg cgcataggtg ttgttgcacg cgggacgggc ggatcacgtg
    12421 gcactgtcac ccgtatccgc gagcagctgg ttcgccttgc ttcatcctcc attgtcgtcc
    12481 gaagtcgtat caaaaaaggc cgcgtggaca ttcattgggg cgtaaaccac cccatcgctg
    12541 gcgaatggga gccgtggttt gacgcagaca atcccgatca agcggctatc caactcactg
    12601 ataggttctt ccagctcata gctgacgctc cgattcctat tgatctcgac atcctgcaca
    12661 agctgggcaa gccacgggca atggacatct atgtgtggat cactgtcaaa aaagccaggc
    12721 tcaattatca gaaccggcct agcttcacgt tctcctggaa gcagatggaa caccagttct
    12781 cccccaaaga actgacaacc tgggcacagc gagctaactt ccgcaaggag ttcaacgggt
    12841 gcctagaaac aatccgtgcc ctatggcctg acgttggtgt ggacacggac actaaggctg
    12901 gcgtaaccct tcacaagagc gccccgtctg taaccatgcg accatcgcgg aaacaactcc
    12961 gctagtccac tttcgataca ccccacaccg cgtcttcatc catgtccacg gccacgtggg
    13021 gcgctgcacg tcggattgcc ggcactctcg gcgggcgtag taccgtcctc ggctcgtttg
    13081 gagccagcga gaccgaccgg cagcaccttc ttgccctcgt aggccttgac cgtgaagttg
    13141 ataaagcatt cggtgcacca cggaagctca caacggagtg ccagcgccaa gagctactgt
    13201 tcgagaacta ctccaagcta acgtcataac gctataacgc taacgctatg acgttgcgac
    13261 gctatggcgc tagaacgtga taacgttgta tgcaggtaga cggcaacaaa aaggaatggt
    13321 gatacatgag agtatcgttc gtccacacca aaggaggtgt aggaaaaacg actagcgcga
    13381 tcatggttgc agcagcagca acccgccatg ggcgcgcagt ggaagtgttc gacactgatc
    13441 cgcaaggatc agcctcgcgg tgggcagaga tcgccgaagg gcgcggtgat accctcccgt
    13501 tccccgttcg ctacctgact gccaacgagc tacggcagct acccgcagac gaatccactc
    13561 ttcagattgt cgataccccg cccggcgaag cagcatccat tcaagccgct atcgataccg
    13621 ccgatctagt agtcgtcccc tcgggtgcat ccccgatgga tattgaccgt gtgtggccaa
    13681 cgatagaaac cattactggc caccccgccg gcgtgttgct caccggtgtg cttatgcaca
    13741 cccggttcta caccgaagca cgccaccttc tcgaagacca aggggtagcc accttttaca
    13801 atgcgatccc ccaacgcgag gaaattaaag cggcgttcgg cactaacccc atccgctttc
    13861 atggctacga cgatgtgtac caagagatct ccgaagttga ggaactgtaa tggctgaaaa
    13921 acgtgcccac cttgccgaca ccctttccaa ggggcgggta ataaagaaaa cgaaaccagt
    13981 gcccgtggcg gatacctttg ccaacaaaga cgttgcgtta gaccggcgca ccacgatcta
    14041 cctgtcgcag gacaactgga aagccctcaa gctccgcagt gtggaggaag ataaaaacct
    14101 ctccgaactc attaacgacc ttgtggccga ctacctttcc gccaagtaga aaccaacgtt
    14161 tcaacgttaa agcgttaagg cgttttagtg ccttaacgct ttatttatgc cctaatggaa
    14221 ctcaaaaagt ggttacgagc tgcgcataac gttaaaacgt tgaaatgtta gcgttaaaac
    14281 gctataacgt taataggggt gtggtagtcc catccgtcca ggt
//
