LOCUS       NC_008264              12206 bp    DNA     circular BCT 05-DEC-2007
DEFINITION  Clostridium perfringens SM101 plasmid 2, complete sequence.
ACCESSION   NC_008264
VERSION     NC_008264.1  GI:110804009
KEYWORDS    .
SOURCE      Clostridium perfringens SM101
  ORGANISM  Clostridium perfringens SM101
            Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 12206)
  AUTHORS   Myers,G.S., Rasko,D.A., Cheung,J.K., Ravel,J., Seshadri,R.,
            DeBoy,R.T., Ren,Q., Varga,J., Awad,M.M., Brinkac,L.M.,
            Daugherty,S.C., Haft,D.H., Dodson,R.J., Madupu,R., Nelson,W.C.,
            Rosovitz,M.J., Sullivan,S.A., Khouri,H., Dimitrov,G.I.,
            Watkins,K.L., Mulligan,S., Benton,J., Radune,D., Fisher,D.J.,
            Atkins,H.S., Hiscox,T., Jost,B.H., Billington,S.J., Songer,J.G.,
            McClane,B.A., Titball,R.W., Rood,J.I., Melville,S.B. and
            Paulsen,I.T.
  TITLE     Skewed genomic variability in strains of the toxigenic bacterial
            pathogen, Clostridium perfringens
  JOURNAL   Genome Res. 16 (8), 1031-1040 (2006)
   PUBMED   16825665
REFERENCE   2  (bases 1 to 12206)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-2006) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 12206)
  AUTHORS   Myers,G.S., Rasko,D.A., Cheung,J.K., Ravel,J., Seshadri,R.,
            DeBoy,R.T., Ren,Q., Varga,J., Awad,M.M., Brinkac,L.M.,
            Daugherty,S.C., Haft,D.H., Dodson,R.J., Madupu,R., Nelson,W.C.,
            Rosovitz,M., Sullivan,S.A., Khouri,H.M., Dimitrov,G., Watkins,K.L.,
            Mulligan,S., Benton,J.L., Fisher,D.J., Atkins,H.S., Hiscox,T.,
            Jost,H., Billington,S.J., Songer,J.G., McClane,B.A., Titball,R.W.,
            Rood,J.I., Melville,S. and Paulsen,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2006) The Institute for Genomic Research, 9712
            Medical Center Dr, Rockville, MD 20850, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CP000314.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..12206
                     /organism="Clostridium perfringens SM101"
                     /mol_type="genomic DNA"
                     /strain="SM101"
                     /db_xref="taxon:289380"
                     /plasmid="2"
     gene            complement(551..3190)
                     /gene="bcn"
                     /locus_tag="CPR_B0001"
                     /db_xref="GeneID:4206646"
     CDS             complement(551..3190)
                     /gene="bcn"
                     /locus_tag="CPR_B0001"
                     /note="identified by match to protein family HMM PF00246"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="YP_699920.1"
                     /db_xref="GI:110804016"
                     /db_xref="GeneID:4206646"
                     /translation="MANNIIPNVSSGDLVGSTPTFPPNAVVRGDFLYLRDVDGNQIPG
                     RTVSDGDEITVLFISNEKNIVLVQYPTSSGYRQGYVTNARSIIKYKDDYSWVNGSTPE
                     PVYDFDKTTQIGTLDPRERAVVLYKVDGMTYVAYDTGKGKLTKSGLVHYEGAGSSTGG
                     GSFNGVAPGEVVPGGFTYENNAEVVGDELYLRDANGNRIPGRSVSVGDKITVLDVSYS
                     KQLALVQYPAGNVVRQGYVTNATNLIRYFNQSMWHNGSTPEEVLDENGGHLGSLDPYE
                     SATPLYKKNGMTHVVYNTSKGPNTKSGYVKYEGSAATRVDIPRPSITNSQKIVYGTSG
                     RGRELAAYKVGNGANSLIYVCAIHGWEDHWAADGIELTRIGNGLIEHFQNAGTNNWSL
                     YIIPVANPDGLSEGYTNNGPGRCTIVGAVDCNRDFPIGFTPYGDSRHWTNKEPLSVPE
                     SRSLRDFISEIKGKTSGSTYLIDMHGWEDKTIGDSHISRAFQNQFGFVNGCYDGVYQG
                     GFLISWANSIGVRAALIELPQSCYSHSDAVNGRYLQKCINAVTNLIGGSGGSSSGGSS
                     SSDITYISNGEVINVQSFLNVRKGPGTDYDSIGQLHQGDKVSIVAKNGTWYKIKYGSG
                     YGYVHSDFVKNDTVLPITPEENDKDKEQAKNKAIEYVKNIIGTEIKLPFNTYKTIIDG
                     IVEIDFKYGLNSYIFPDAAINLNIEEGKLKANNNAGNLMLMFLDIYKKKNPLVRFLLN
                     KLIYKIEEGEISIEINPAELSIEISIASKLYENKKFEMGNKVFFSLLFKINNDEIEKI
                     KKELGEVAKEVLDELVSLINYLMENADNVFLGVLMVVLVILAAFYLVPALAASLGVTA
                     GVTALSEAIAAILVAVKAMPTLK"
     gene            complement(3443..3637)
                     /gene="uviB"
                     /locus_tag="CPR_B0002"
                     /db_xref="GeneID:4206643"
     CDS             complement(3443..3637)
                     /gene="uviB"
                     /locus_tag="CPR_B0002"
                     /note="identified by similarity to SP:P15936"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin UviB"
                     /protein_id="YP_699921.1"
                     /db_xref="GI:110804013"
                     /db_xref="GeneID:4206643"
                     /translation="MDSELFKLMATQGAFAILFSYLLFYVLKENSKREDKYQNIIEEL
                     TELLPKIKDDVEDIKEKLNK"
     gene            complement(3718..4290)
                     /locus_tag="CPR_B0003"
                     /db_xref="GeneID:4206645"
     CDS             complement(3718..4290)
                     /locus_tag="CPR_B0003"
                     /note="identified by match to protein family HMM PF04545"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin uviA"
                     /protein_id="YP_699922.1"
                     /db_xref="GI:110804015"
                     /db_xref="GeneID:4206645"
                     /translation="MGRVRMSELYKNIVLCQKGDKKAIEYIINKFEILINKYKMSFLK
                     EIHFNSYDVEDNKQDLIVSLINIVNKIPIDNPQFENEGCLVNYIYRSILNSRKDMYIN
                     KNIKRYFIESQSLSSMVEFKDKPLVKYIESNIEIEDMLKCLTEKEQKVIKYKFLNDKS
                     EVEIAEIMGTSRQWINRIKNTALKKLKENI"
     gene            4586..5614
                     /locus_tag="CPR_B0004"
                     /db_xref="GeneID:4206641"
     CDS             4586..5614
                     /locus_tag="CPR_B0004"
                     /EC_number="3.5.1.28"
                     /note="identified by match to protein family HMM PF01520"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase domain
                     protein"
                     /protein_id="YP_699923.1"
                     /db_xref="GI:110804011"
                     /db_xref="GeneID:4206641"
                     /translation="MKIAIRGGHNFLAKGACGLIDETIEDRKVYKAVIKNLIENNFEV
                     LDVTPDDCDVNTDLKFGVEKANNFNADLFVSIHFDKCYDKFDGPLGTGTWVCEKGGKA
                     EIYAQNIVDTISEGTSLKNRGVKTNAKLYELNKTIMPAVIVEVCFCESKVDVDIYREK
                     GSDLIGYLIAKGICKSVNKEISSDLPQVNLENTTNSQNNNLFKTNATAKVALDPRDNP
                     SNNYKDLGEIYANERIKILAEVCDLKFFLPATYWQDALNKESSPIWVNSKQTVLNVDT
                     NATVINVLTELDARYTPSPDSNRMGYVKNQERLFVHKIENNYALATYLASEGYKTAWF
                     TAEYIKLD"
     gene            complement(5707..6063)
                     /locus_tag="CPR_B0005"
                     /db_xref="GeneID:4206644"
     CDS             complement(5707..6063)
                     /locus_tag="CPR_B0005"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_699924.1"
                     /db_xref="GI:110804014"
                     /db_xref="GeneID:4206644"
                     /translation="MIWSKLSSSINYYINKRIWGEELLKENILLLNQYIEDAFILEDG
                     IYKYLDKKTYEYIDLSEEDMKKIEEAFIERLEKKRKVNKDKENFKNHMIMITEYLENE
                     KIKEKSNVIELKNYRK"
     gene            complement(6089..6658)
                     /gene="res"
                     /locus_tag="CPR_B0006"
                     /db_xref="GeneID:4206642"
     CDS             complement(6089..6658)
                     /gene="res"
                     /locus_tag="CPR_B0006"
                     /note="identified by similarity to SP:P07945; match to
                     protein family HMM PF00239; match to protein family HMM
                     PF02796"
                     /codon_start=1
                     /transl_table=11
                     /product="resolvase"
                     /protein_id="YP_699925.1"
                     /db_xref="GI:110804012"
                     /db_xref="GeneID:4206642"
                     /translation="MLVGYARVSTEEQSLNRQIDMLIDYGVDKRNIYQEKISGMKSNR
                     EQLDKMIYELQAGDTVIITDLTRISRSTKDLLNIIDRIKAKGASIKSIKDTWLDTSSD
                     NPYNSFLLTVMSGLSQLERDLISQRTKEGLKSAKARGRNGGRPSKRNDKAHTVGLLYR
                     EGYKIVDIVKQTELSRATVYRVLNDLKLK"
     gene            complement(6875..7315)
                     /locus_tag="CPR_B0007"
                     /db_xref="GeneID:4206639"
     CDS             complement(6875..7315)
                     /locus_tag="CPR_B0007"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_699926.1"
                     /db_xref="GI:110804010"
                     /db_xref="GeneID:4206639"
                     /translation="MFNLYNEFLKYEYNELNELFKMAKTKEEQDFYIALCNFKLQKEQ
                     KKVIGNDFEIEVTLNEILNWVECETFRLNLPDSKTFYFSSEKSNDNYDFKIFKCFSSD
                     KDIKNLKNIIRSEIESVNNEYSVCKIIVNVRFGSLTFYFRNKKI"
     gene            complement(7565..8542)
                     /locus_tag="CPR_B0008"
                     /db_xref="GeneID:4206648"
     CDS             complement(7565..8542)
                     /locus_tag="CPR_B0008"
                     /note="identified by match to protein family HMM PF00589"
                     /codon_start=1
                     /transl_table=11
                     /product="Phage integrase family domain protein"
                     /protein_id="YP_699927.1"
                     /db_xref="GI:110804018"
                     /db_xref="GeneID:4206648"
                     /translation="MPNISKYEVLEWIGVIFMSKKKNRNINGQITYAINKCFKEGMDK
                     RAYKIQEGRSMGDKVFSYAEKYRLKDMAKSLQKFLKDNGRDVKYVKDIQSEDIQGYLE
                     SAKARGCTQNTIDTYANSLFKIQEAINATYGVKTNWRSEISIPVAEKAQSGDRGANSV
                     ITRDDYNKILDYAEKNISESGYAIRLQDFLGVRVEEVARISRDNINLEDRTIKLVNTK
                     GGRELTREIPNDRVELVKEVLEHNYHEDRLFSINGDSINRYLNRIEDKLGIERHSNHD
                     IRRLIAQEKFDSYRKSGLSIKDAANKTSAWLSHGDNRNELLEKSYIKLK"
     gene            complement(9367..9867)
                     /locus_tag="CPR_B0009"
                     /db_xref="GeneID:4206649"
     CDS             complement(9367..9867)
                     /locus_tag="CPR_B0009"
                     /note="identified by match to protein family HMM PF04394"
                     /codon_start=1
                     /transl_table=11
                     /product="Protein of unknown function, DUF536 family"
                     /protein_id="YP_699928.1"
                     /db_xref="GI:110804019"
                     /db_xref="GeneID:4206649"
                     /translation="MLRGVDEVAKELKVSKTAIYNKLKLKEFKHKVVKKQGKSMIDEE
                     LLTLLKDSLKVKNKVEYKDYIEENKGEVKSEIAIDREGSLNLNKSLIDALIVQLEEKD
                     KQIAELHKLIENNQVLLKKEQETKVNILELEDHFKEVDNKLNSIKEKMNQRKEKKSFF
                     KNFFKK"
     gene            complement(10401..11621)
                     /locus_tag="CPR_B0010"
                     /db_xref="GeneID:4206647"
     CDS             complement(10401..11621)
                     /locus_tag="CPR_B0010"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein"
                     /protein_id="YP_699929.1"
                     /db_xref="GI:110804017"
                     /db_xref="GeneID:4206647"
                     /translation="MEYALKLNKINYIDNVHSNSKGWITRSVIDKKGYSQWHYKYAEL
                     KDLDMSGENIYITLNTFYKPCRRLENIKELNTLFIDLDYYKTCKTKDQVLMDLEKNYF
                     NQSIPIPNYVIDSGRGMYLIWIINAVPSKALPLWKAVQEYLYNQLKYFGADRQALDAT
                     RILRVPGSINSKSKTVVNILDEYEYIYDLREIQNGFLPELKPYEKKKGRPSKINYIYR
                     ERSLYYGRIQDIIKLCELREYDLKGHRELILFLYRYYLCSFTEDIQKALEDALELNSM
                     FRQALSEREVIRATRSAERCYLDKNKQYKYKNETLIELLEITEEEQKYMTIIISKKEY
                     KRRENIRGKKNYQEKLKSQGKFTEKEKISQRRKKILDLLAEGLKQKDICIFLNISKPT
                     YVRDRNFLKEQGLI"
     gene            complement(11729..12176)
                     /locus_tag="CPR_B0011"
                     /db_xref="GeneID:4206640"
     misc_feature    complement(11729..12176)
                     /locus_tag="CPR_B0011"
                     /note="similar to Hypothetical protein"
ORIGIN      
        1 actaaaaaac taggattttt tacgtataaa tcataatttt ctctagctac aataatcccg
       61 acatcaacaa tatgcatttt attgttatta atttcattta atatgttatc agaagatata
      121 aaataagctt tatcaggaaa tttaacacta cctgtaatat taaaatctcc ttcttctata
      181 ggtgaaccat cctttgtctc aacattataa tcaaaaagaa cataatgatt gaataatttc
      241 ggcttattta tttgaacttt atagttatca aattctacat tatacggaaa ttgtgtttcc
      301 acttctttag tttcctctat ttttgtggta ttaaatctct tacccgatat tttaaaacac
      361 agaagtataa gacttaacaa taaaattata cttataaaaa tactaattgg agataatctt
      421 ttttttgttt tcattcgcta ttcctttcaa atatattgta ttttataatt taaaatattt
      481 ttaataatta tagcataaaa gttatatgtc atagatggat tctatgatat ataactctta
      541 aataatatta ctattttaat gttggcattg ctttaactgc tacaagtatc gctgcaattg
      601 cctctgataa agctgttact cctgctgtta ctcctaaaga agctgctaat gctggtacta
      661 aataaaatgc tgctaaaatt accaatacaa ccataagaac acctaaaaat acattatctg
      721 cattttccat taaataattt attaaactta ctaattcgtc caatacttct tttgcgactt
      781 ctccaagttc ttttttaatc ttttctatct catcattatt aattttaaac aataagctaa
      841 agaaaacctt atttcccatc tcaaactttt tgttttcata taactttgat gctatagata
      901 tttctataga tagctcagcc ggattaattt ctattgaaat ttctccttct tcaattttat
      961 atataagttt atttagtaaa aatctaacta atggattttt ctttttataa atgtcaagga
     1021 acatcaacat taaatttcct gcattattat tagcttttaa ctttccctct tcaatattaa
     1081 gatttattgc agcatcagga aatatataac tatttaatcc atatttaaaa tcaatttcca
     1141 caattccatc tattattgtt ttatatgtgt taaatggtaa cttaatttca gttccaatta
     1201 tatttttaac atattctata gctttattct tagcttgttc tttatcctta tcattctctt
     1261 ctggcgtgat aggcaacact gtatcatttt taacgaaatc agaatgtaca taaccatagc
     1321 ctgaaccata ttttatttta taccatgttc catttttagc tactatgctt accttatctc
     1381 cttgatgcaa ctgtcctatt gagtcataat ctgttcctgg tccttttctt acatttagga
     1441 aggattgtac atttattact tctccgtttg atatataagt tatatctgaa gatgaacttc
     1501 ctcctgatga actaccgcca gaacccccta ttagatttgt tactgcattt atacactttt
     1561 gaagatatct tccattaaca gcatctgaat gactataaca tgattgtggt aattctatta
     1621 aggctgctct tactcctatt gaatttgccc atgatattaa aaatcctcct tgatatactc
     1681 catcataaca tccatttaca aatccaaatt gattttggaa tgctcttgat atatgtgaat
     1741 ctcctattgt cttatcttcc catccgtgca tatctattaa atatgttgaa cctgatgtct
     1801 ttccttttat ttcacttata aagtcacgta aacttcttga ttctggtaca cttaacggct
     1861 ctttatttgt ccaatgtctt gaatctccat atggtgtaaa tcctattggg aaatctctat
     1921 tgcaatctac tgcacctact atagtacatc ttcctggccc attatttgta tatccttctg
     1981 ataatccatc tggatttgct actggaatta tatatagtga ccaattgttt gttcctgcat
     2041 tttggaagtg ctctataagt ccattaccta ttctagttaa ctcaatacca tctgctgccc
     2101 agtgatcttc ccatccgtgt attgcacata catatatcaa tgaattagct ccattaccaa
     2161 ctttataagc tgctaattct cttcctcttc cacttgttcc atatactatt ttttgtgaat
     2221 ttgttattga tggtctaggt atatccactc tagtagctgc tgaaccttca tattttacat
     2281 aacctgactt tgtgttaggt cctttggatg tattataaac aacatgtgtc attccatttt
     2341 tcttatatag tggtgttgct gattcatatg gatctaatga tcctaaatgt ccaccatttt
     2401 catctaatac ttcctctggt gtacttccat tgtgccacat actttgatta aagtacctta
     2461 ttaagttagt tgcatttgtt acataaccct gtcttactac attgccagct ggatactgta
     2521 ctaaagctaa ttgcttgcta taactaacat ctaaaacagt tattttatct cctacactta
     2581 cacttctacc tggtattcta ttaccatttg catctcttag atatagttca tcaccaacta
     2641 cctctgcatt gttttcatat gtgaatccac ctggtacaac ctctcctggt gctactccat
     2701 taaaacttcc gcctccagta gaactaccag ctccttcata atgaactaat cctgactttg
     2761 taagcttacc ttttcctgta tcataagcaa catatgtcat tccatctact ttataaagaa
     2821 ctacggctct ttctcttgga tctaatgttc ctatttgtgt tgttttatca aagtcatata
     2881 ctggctcagg tgttgaacca tttacccatg aataatcgtc tttgtatttt attatgcttc
     2941 ttgcatttgt tacatatcct tgtctatatc cagaacttgt tggatattga actaatacta
     3001 tatttttttc attacttata aataaaactg taatttcatc tccatcactt actgttcttc
     3061 ctggaatttg attaccatca acatctctta gatataaaaa atctcctctt actactgcat
     3121 ttggcggaaa cgtaggtgta cttcctacta aatcccctga actaacattt ggaattatat
     3181 tgtttgccat ttttaaaacc tctcttttct ttatttttta tttgaattta atcttttaaa
     3241 tttttctttt tacaaaaatc aagcttgaat ttgttttaca taatataaag agtaatttga
     3301 cttcaatttt gtaaactaaa tttataattt ttttattttt ttgaaattta aattactctt
     3361 tataaataaa aagagtttag ttttaaaaat gtaaacctaa aaattaaaaa agccgatatt
     3421 ttttaaatat cgacttctca tcctatttat taagtttttc ttttatatct tctacatcat
     3481 cttttatttt tggcaataat tctgtaagct cctctattat attttgatac ttatcttctc
     3541 ttttactatt ttccttcaaa acataaaaca ataaatacga aaataatatt gcaaaggctc
     3601 cttgtgttgc cattaactta aataattcac tatccatttt agctaacctc caatccattt
     3661 ttatttaaca attcaagcct aatttttgtc tttaataaaa atagattaaa ttaataacta
     3721 aatattttct tttaattttt ttaaagctgt attctttatt ctatttatcc attgtcttga
     3781 tgttcccatt atttcagcta tctctacctc acttttatca tttaaaaatt tatattttat
     3841 aaccttttgt tctttttctg taaggcattt tagcatatct tcaatttcaa tattagattc
     3901 tatatatttt accaaaggct tatctttaaa ctctaccatg cttgataaag actgactttc
     3961 aataaaatat ctttttatat ttttatttat atacatgtcc tttctactgt ttaatattga
     4021 tctataaata taattaacta aacacccttc attttcaaat tgaggattat caataggtat
     4081 tttattaact atatttatta aactaactat taaatcttgt ttattatctt caacatcata
     4141 actattaaaa tggatctctt taagaaaaga cattttatat ttattaatta atatttcaaa
     4201 cttatttatt atatattcta tagccttttt atctcctttt tgacataata ctatattttt
     4261 atataattca ctcatacgca ctctacccat attaatttat tttttgcatg gtagagtgtt
     4321 ttttttttta ataaaatgtt ctatttttaa tacgaacata tgttcgtatt aattttacaa
     4381 ctttttcaca aataagtcaa taaacccaaa caatataaaa atagactaaa agcttatact
     4441 atataaaaag ctttttttag tctattttgt aaatatctat tttttataaa aatctaactt
     4501 tctttaattt ttatgtttac aaaatcaaat cctaacactt tttaatatat aagaacataa
     4561 aaatttaaga aagaaaggtg ataatatgaa aatagctata cgtggtggac ataacttttt
     4621 agcaaaaggt gcttgtgggt taatagatga aactatagaa gatagaaaag tttataaagc
     4681 tgttattaaa aacttaattg aaaataattt tgaagtttta gatgttactc cagatgactg
     4741 tgatgtaaat acagacttaa aatttggagt agaaaaagct aataatttta atgcagattt
     4801 attcgtttct atacactttg ataaatgtta tgacaaattt gatggtcctt taggtacagg
     4861 aacttgggtt tgtgaaaaag ggggaaaagc agaaatatat gctcaaaata tagtagatac
     4921 aatctctgaa ggaacttcct taaaaaatag gggagttaaa actaatgcta agctttatga
     4981 attaaataaa acaatcatgc cagctgtaat agttgaagtt tgtttctgcg aatctaaagt
     5041 agatgtagat atttatagag aaaaagggtc tgatttaatt ggttatttaa tagctaaagg
     5101 aatttgtaaa tctgtaaata aagaaattag ttctgatttg cctcaagtta atcttgagaa
     5161 cactactaat tcacaaaata ataatttatt taaaactaat gcaacagcaa aggttgcttt
     5221 agatcctagg gataacccta gtaataacta caaagattta ggtgaaatct atgcaaatga
     5281 aagaataaaa attttagctg aagtttgtga tttaaaattt ttcttaccag caacatattg
     5341 gcaagatgca ttaaataaag aatcttctcc tatatgggta aattcaaaac agacagtact
     5401 taatgttgat accaatgcaa ctgtaatcaa tgttttaacc gaattagatg ctagatatac
     5461 tccttctcct gattcaaata gaatgggata tgtaaaaaat caagaaagac tttttgttca
     5521 taaaattgaa aataattatg ctttagctac ttacttagct agtgaaggat ataaaacagc
     5581 atggtttaca gcagagtata taaaattaga ttaataatct ttaataaata taatagaaaa
     5641 agactaaaaa agttatatta ctttttagtc tttttttatt aactaatatt cttttaaaat
     5701 aacacattat tttctataat tttttaattc tataacatta cttttctctt taattttttc
     5761 attttctaaa tactcagtaa tcattatcat atgattttta aaattttctt tgtctttatt
     5821 tacttttctt tttttctcta atctctcaat aaaagcttcc tctatttttt tcatatcttc
     5881 ttcacttaga tcaatatact catatgtttt tttatctaaa tatttataaa taccatcctc
     5941 aagtatgaac gcatcctcaa tatattgatt taataataaa atattttctt ttaaaagttc
     6001 ttctccccat attctcttat taatataata atttatactt gagcttaact tgctccatat
     6061 catactctca tcccctttaa tatatttttt attttaattt taaatcattt agcactctat
     6121 atacagttgc tctacttaat tccgtttgtt ttactatatc aactatttta taaccttccc
     6181 tatatagtaa ccctactgta tgggctttat catttctctt ggaaggcctt cctccattcc
     6241 ttcccctagc ttttgcgctt tttaaacctt ctttagtcct ttgacttatt aagtccctct
     6301 ctaattgact caatccactc ataacagtta gtaaaaaact attatatgga ttatcacttg
     6361 atgtatctag ccaagtatct ttaatacttt ttatactagc tcctttagct tttattctat
     6421 ctataatatt aagtaaatcc tttgtacttc ttgatattct ggtcaaatca gtaattataa
     6481 ctgtatctcc tgcttgtagt tcatatatca ttttatctag ctgctctcta ttagatttca
     6541 ttccacttat tttttcttga tatatatttc tcttatctac accataatca attaacatat
     6601 cgatttgtct atttaaactt tgttcttcag tactaaccct tgcatatcca actaacataa
     6661 ttttatctcc attttttcta aatttatttc ttttattata ccaaaaaggt atcataatct
     6721 aaatagatta tgataccttt tttaatacat ttttgcatag aaaatttggc ttttttctat
     6781 acaaaaaaat aatgtataaa aaattaccgt ttttgatact aataataaat tttttaaatt
     6841 ttaaatatat aagaacacca aaagaaagta aattttatat ttttttattt ctaaaataaa
     6901 aagttaatga tccaaatctt acatttacta ttattttgca aacactatat tcattattaa
     6961 cactttctat ttcagatctt attatatttt ttaaattttt aatatcttta tcagagctaa
     7021 aacatttaaa tattttaaaa tcataattat cattgctttt ttcacttgaa aaataaaaag
     7081 ttttactatc tggtagattt aatctaaatg tttcacactc aacccaattt aatatttcat
     7141 ttaaggttac ctcaatttca aagtcatttc caataacttt cttttgttct ttttgtaatt
     7201 taaagttaca caatgctata tagaagtcct gttcttcttt agttttagcc attttaaaca
     7261 gctcatttaa ttcgttatat tcatatttta aaaattcatt atacaaatta aacataatat
     7321 ttaactcctt aaaattaatt aatataaaaa gaagatagac cctatatttt ttcaatgtcc
     7381 tcaaaataag gaacttcata aataaatata aaatttatct tctttttagt gttttggtaa
     7441 tgaatgtttg caattttaaa ataaaaagta aatactagat tttcaattac cagtaaacaa
     7501 aatcacagta ttaatataaa ttttaaatta agataagatt ttaaacaata aaaaccagaa
     7561 gaatttattt tagttttata tagctctttt caagaagctc atttctatta tctccatgac
     7621 ttaaccaagc acttgtttta ttagctgcat ctttgatact taaaccagat tttctataac
     7681 tatcaaattt ttcttgagct attaatcgcc ttatatcatg gttactgtgc ctttctattc
     7741 ctagcttgtc ctctattcta tttaaatatc tatttataga atctccattt atactaaata
     7801 atctatcttc gtggtaatta tgttctaata cttctttaac aagctctact ctatcatttg
     7861 gaatttctct tgtaagttct cttccccctt ttgtatttac aagttttata gttctatcct
     7921 ctaaatttat attatctcta cttatgcgag ccacttcctc aactctaacc cctaaaaagt
     7981 cctgtaatct tatagcatat ccgctttcac taatattttt ttctgcataa tctaatattt
     8041 tattataatc atctcttgtt ataacactat ttgctcctct atcgccactc tgagcctttt
     8101 cagctactgg aatagatatt tcactcctcc aatttgtttt aacgccatat gtggcattta
     8161 tagcctcttg aattttaaat aagctattcg catatgtatc tattgtattt tgtgtgcagc
     8221 ctctcgcctt tgcactttct aagtagcctt gaatatcttc cgattgtata tccttcacat
     8281 acttaacatc tcttccattg tcctttaaaa atttttgtaa agatttcgcc atatctttaa
     8341 gtctgtattt ttctgcataa ctaaaaactt tatcacccat ggatcttcct tcttgaatct
     8401 tatacgctct tttatccatc ccttctttaa aacatttatt tatggcatat gtaatctgtc
     8461 cgttaatatt tctatttttc tttttactca taaaaataac tccaatccat tctaaaacct
     8521 catatttact tatgttcggc attaacaggc tccctatgtc cgcctgttaa tgccgacatt
     8581 gaagataata aaaactaaaa aataataaaa gcttttttat ttcaatcaca attttcctcc
     8641 tcgtggaaaa ctaaataaaa tccgctattt aagcttttta aaaatagccg tcgatttttc
     8701 aagttcctaa atagaaccta caaaatgtct attaaaaaat agacactaaa ataatattgc
     8761 agctccgcag caaattaatt ttttgcattt tacaaatgca aaaaattaat ttggtatcct
     8821 gttttttaaa aattttaaac ataaaatttt taaaaaacta aatttatata taaaaaaaca
     8881 aataaaaaaa acctaaccaa ttttaaaaat ttaaaactaa ataattagta agtggctata
     8941 ccactataaa aagactcatt aaactccagt aaaaactact ggccaatact aatatttgtt
     9001 ttattcttta aaatttttag atttatctat ttgttattaa tctatgctta taaaatataa
     9061 gctaatattt atttttttat gttaatctta gtctttaaaa gaccctttta aaatttaagt
     9121 aatcctaagc tttagcttaa aaaaatttaa gttatcttaa acctatagtt taaaaaattt
     9181 gaatataagc taaaaacttt ttcaacttat attgtaataa tctattaatt taattttata
     9241 acattttaaa agtttaatca aattcttaac ttatttatta ttttaatttt ttctttcctg
     9301 aaataattaa aataatacac ttactaaaaa ataattttta tcctatatct ttaatctatt
     9361 aaaaatttat tttttaaaaa agtttttaaa aaaacttttt ttctcttttc tttgattcat
     9421 tttttctttt attgaattca atttattatc aacttcttta aagtgatctt caagttccaa
     9481 tatattaacc ttagtttctt gttctttttt taaaagtacc tggttattct ctataagctt
     9541 atgtaactct gctatctgct tatctttttc ttcaagttga acaattaaag catcaattaa
     9601 acttttattc aagtttaatg aaccttctct atcaattgct atttctgatt ttacctctcc
     9661 tttattttcc tctatataat ctttatattc aactttattt ttaactttta aactatcttt
     9721 aagcaaggtc aataattcct catcaatcat tgatttacct tgctttttaa ctactttatg
     9781 tttaaactct tttaacttaa gtttattata tatagcagtt ttactaactt ttaattcctt
     9841 agctacctca tctacacctc ttaacataac taacttcccc taattccatt aaactttaat
     9901 cctatttaat taattctaaa caataataga ttttcctttt ttatagattt aattacttta
     9961 ataaaacttc atggaaaaac tttttgaaag tattaaaaag agcataagga gaaattgcta
    10021 tcaccaaagg ttctagtcta gtcaaagcct agtatttcaa tgctatcaaa gtaatttcca
    10081 attatcccac tctaagccac aaaaacgccc tataaaatcc cgctttaatc ccactttgag
    10141 acacatataa tattacttta cgccctagta tagtgataat tttttacatt caatgccacg
    10201 caaaaaatta aaggggcact ataataaaag ttccttcgga actaactaaa gtaaaaaatt
    10261 atctttacaa cctccccaaa aaaagaacag gtacaaagta ccctataata caagcgtaaa
    10321 aaatttgata cctatttaaa actatttaaa agttaattgc ttaatataaa attttatttt
    10381 ataatacaaa aagaacatgg ttatattaaa ccttgttctt ttaaaaagtt tctatcacga
    10441 acgtaagttg gtttagatat atttaaaaag atacatatat ctttttgttt tagaccttct
    10501 gccaaaaggt ctaatatttt ttttctacgt tgtgaaattt tttctttttc agtaaattta
    10561 ccttgagatt ttaatttctc ttggtaattt tttttacctc taatattttc tcttctctta
    10621 tattcctttt tagaaattat tattgtcata tatttttgtt cttcttctgt aatttctaat
    10681 agctctataa gagtttcatt cttatactta tattgcttat ttttatctaa ataacatctt
    10741 tcagcacttc tagttgctct tataacttct ctttcactta aagcttgtct gaacatacta
    10801 tttagttcta aagcatcttc taaagccttt tgaatatctt ctgtaaagct acaaagataa
    10861 tatctatata aaaataatat aagttctcta tgccctttta aatcatattc tcttagttca
    10921 caaagtttta ttatgtcttg tattcttcca taatataaac ttctttctct ataaatataa
    10981 tttattttac ttggtctacc ttttttcttt tcatatggtt tcaattcagg taaaaatcca
    11041 ttttgtattt ctcttaaatc ataaatatat tcgtactcat ctaatatatt gactactgtt
    11101 tttgatttag agtttatact tcctggaact cttaatatcc tggttgcatc taaggcttgt
    11161 ctatctgctc caaagtattt taattgatta tataaatatt cttgaactgc tttccataat
    11221 ggtaatgctt tactaggtac tgcatttatt atccatatta aatacattcc tctcccacta
    11281 tctattacat agtttggtat aggaatactt tgattaaaat aattcttttc taagtccatt
    11341 aatacctgat ccttagtttt gcaagtttta taataatcta agtctataaa taaagtattc
    11401 aattccttta tattttctag ccttctacaa ggcttataga acgtatttag agttatataa
    11461 atgttttcac cactcatatc taaatctttc aattcagcgt atttatagtg ccattgacta
    11521 tatccttttt tatctataac gctcctggtt atccaccctt tactgttact atgaacatta
    11581 tctatatagt ttatcttatt cagttttaat gcgtattcca ctttttcacc tccccttttg
    11641 taaaactaag aaaattatat cacaaatata tttataaaaa aatttgcaat aaaatttatt
    11701 gcaaatctct aatctcatga aaattttagt ttattttaac ttcttcatta gtatttttat
    11761 taataagata tatttccata ttatctctac ttacctcatt aggattatat aaaatttttg
    11821 ccatatagaa ttgatcatat tctgaatttt tattatattt agaatctatc ttactataat
    11881 tttttatggc tttttcataa aatccagccc atttttctaa attataaatt tgatttaaat
    11941 ttccacattt aattctaata gcatatttat tacttatttc ttcactttgt tcatgactta
    12001 tattacctat aaaaataggt ataaatgatc caaaatcaaa atttcctaaa cttaaaatat
    12061 taaaatcaat attatctaat ttaaatgttt tatttatttc tttatagttt tctttagttg
    12121 gataaataat tcctttagtt tctatccttt tatctattct tttttcttca taaatcaatt
    12181 tgctactacc tttttctctt gcattt
//
